The discovery of
immunoneuroendocrine communication may alter immunotherapy
(Homeostasis-April 21, 2003)
The discovery of
immunoneuroendocrine communication may alter immunotherapy by leading to
more specific therapy of several human autoimmune diseases.
"The complex
communication between the immune and neuroendocrine
systems is
bidirectional, and involves sharing different ligands and receptors in
tissues and organs in vertebrates in general, and mammals in particular. It
has been demonstrated that many hormones, neurohormones, and
neurotransmitters have profound effects on the immune system, and in turn,
cytokines produced by cells of the immune system cause important changes in
neuroendocrine function.
"It has been shown in
different animal models with induced and spontaneously occurring autoimmune
diseases, that alterations of the immunoendocrine interactions are involved
in the breakdown of self-tolerance, and thus homeostasis," researchers in
Mexico report.
"This review discusses
the role of the neuroimmunoendocrine interactions in maintaining the
homeostasis of mammals, and their role in the development of some autoimmune
diseases. The finding that defective immunoneuroendocrine communication
could exist may lead to more specific therapy of several human autoimmune
diseases," wrote M. Arteaga and colleagues.
Arteaga and coauthors
published their study in Revista de Investigacion Clinica (Immunoneuroendocrine
communication network and the regulation of the homeostasis: the use of
hormones and neurohormones as immunotherapy. Rev Invest Clin,
2002;54(6):542-549).
The contact person for
this report is J.M. Montor, University Nacl Autonoma of Mexico, Institute
Invest Biomedical, Department Immunology, AP 70228, Mexico City 04510, DF,
Mexico.
The information in this
article comes under the major subject areas of Endocrinology, Proteonomics
and Immunology. This article was prepared by Immunotherapy Weekly editors
from staff and other reports.
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