SAN DIEGO (Ivanhoe Newswire) -- Most nosebleeds are distracting but go
away after a few drops. Imagine having a nosebleed every day of your life … and
instead of a few drops, it's a few pints of blood. That's reality for people
with HHT, a genetic disorder that affects blood vessels. It impacts one out of
every 2,000 people in the U.S. and more than 6 million people worldwide. One
doctor is experimenting with a cancer drug to stop the bleeding.
It if has an engine and four wheels, it has a place in Jack Sardisco's heart.
The former air traffic controller loves spending his retirement under the hood
of his favorite cars.
Since his youth, Sardisco has been dealing with a debilitating problem --
chronic nosebleeds.
"It gushes out," Sardisco told Ivanhoe. "It doesn't jus trickle down. It gushes
out. I'm talking about full-sized bath towels, six or seven bath towels full of
blood."
He inherited a disease called HHT -- his blood vessels don't work properly. The
slightest movement triggers dangerous nosebleeds several times a week.
"I was on the ground on the floor of the bathroom, like that close to passing
out," Sardisco said.
There are laser treatments, but they don't last.
"We didn't have a treatment," Terence Davidson, M.D., director of the UCSD Nasal
Dysfunction Clinic in San Diego, Calif., told Ivanhoe. "All we had was something
to put a Band-Aid on it."
Dr. Davidson is trying an off-label approach. He's using a cancer drug in low
doses to stop the bleeding. The drug stops new blood vessel growth.
"I worried about it, trust me, but we did it," Dr. Davidson said. "All of a
sudden, I was getting complete control for two years."
In
a study, Dr. Davidson used Avastin on 10 patients. Injections -- which require
surgery and anesthesia -- controlled bleeding for up to two years. A nose-spray
form worked for four months. In three years, he has used the treatment on more
than 50 patients in all and seen no side effects. There are no long-term
results, and the drug can interfere with wound healing.
"Never in my life have I been able to treat people with a nosebleed a day, and
now all of a sudden, that's routine," Dr. Davidson added.
Sardisco comes into the office for a dose of the spray every couple of months.
He's had one nosebleed in seven months, one of his best years so far.
"I'm really hopeful that I can live my life -- a normal life," he said.
For the first time in his life, Sardisco says he's in the driver's seat.
The cancer drug Avastin is FDA-approved to treat colon cancers but is not
approved for this use. Doctors have also used it successfully off-label to treat
eye disorders. Dr. Davidson says because this is still considered clinical
research, patients cannot get a prescription for the nose spray to use at home.
Sourec : Ivanhoe Newswire
