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Drug Makes Asthma Easier to
Manage
Reported February 1, 2007
(Ivanhoe Newswire) -- Children 2 to 14 years old with intermittent
asthma fare well on a common drug used to treat more serious forms of
asthma.
Intermittent asthma is diagnosed when a child (or adult) has brief episodes
of wheezing, coughing or shortness of breath no more than twice a week.
According to researchers, it is the most common type of asthma in children.
Researchers from the Royal Children's Hospital in Melbourne, Australia,
studied 202 children with intermittent asthma to determine if the drug
montelukast could help. Montelukast, marketed as Singulair in the United
States, is commonly used for persistent asthma to prevent asthma flare-ups
from occurring. The oral medication reduces the swelling and inflammation of
airways. It does so by relaxing the walls of the bronchial tubes to allow
more air to get into the lungs.
Results of the study reveal kids who received montelukast had fewer
unscheduled trips to the doctor and missed fewer days of school than kids
who received a placebo. The parents of kids receiving the drug also took
fewer days off work to care for their children. After one year, children who
received montelukast had 163 unscheduled trips to the doctor for their
asthma, while those on placebo had 228 unscheduled visits.
Colin F. Robertson, M.D., from the Royal Children's Hospital, reports,
"Symptoms were reduced by 14 percent, nights awakened by 8.6 percent, days
off from school or childcare by 37 percent and parent time off from work by
33 percent.
A key component of the study was the impact of asthma on the family, as
measured by days absent from school or childcare, nights of disturbed sleep,
and the number of parent days lost from work."
Researchers designed the study so parents would initiate therapy on an "as
needed" basis. Dr. Robertson reports, "The strategy of parent-initiated
therapy required children on average to take the study drug only 30 days per
year, rather than 365, providing a further cost-benefit for the family."
According to the American Academy of Allergy, Asthma, and Immunology, 9
million children younger than 18 have been diagnosed with asthma in the
United States.
SOURCE: American Journal of Respiratory and Critical Care Medicine,
2007;175:323-329
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