(Ivanhoe Newswire) -- A molecule made up of cat and human proteins to block
cat allergies successfully prevented allergic reactions in laboratory mice and
in human cells. Researchers say this discovery could lead to a new therapy for
cat allergies as well as severe food allergies.
Researchers from the University of California, Los Angeles, created a
molecule called GFD (gamma feline domesticus), with an allergy-inducing cat
protein on one end and a human antibody on the other. The human antibody end
binds to surface cell proteins different from the ones the cat protein binds to,
which interrupts the allergic reaction.
Results show GFD reduced the amount of histamine (the chemical responsible
for the itchy, watery eyes, and sneezing symptoms) by 90 percent when it was
tested in blood donated by people who were allergic to cats.
The molecule also proved successful when tested in two groups of cat-allergic
mice. One group was genetically engineered to have human cat-allergy cell
receptors, the other set was injected with cat allergen and an immune system
booster. GFD blocked allergic reactions in both groups.
Researchers believe the molecule may be able to prevent allergic reactions
long after injections stop and hope this type of therapeutic approach can work
to prevent severe food allergies.
SOURCE: PLOS Medicine, 2004;2(3):e78