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Vitamin D3 fights colon cancer
Reported July 10, 2009
(Ivanhoe Newswire) -- The active form of vitamin D3, essential to
calcium absorption and bone health, also seems to have anticancer effects.
To try and understand the underlying mechanisms, researchers set out to
identify genes whose expression in a human colon cancer cell line was
altered by the active form of vitamin D3. The researchers identified one
gene which is responsible for making the protein cystatin D.
Now, another team of researchers at the Consejo Superior de Investigaciones
Científicas-Universidad Autónoma de Madrid, Spain, and the Universidad de
Oviedo, Spain, has studied this protein in detail and has determined that it
has the ability to suppress tumors and likely accounts for some of the
anticancer effects of the active form of vitamin D3.
The team, led by Alberto Muñoz and Carlos López-Otín, initially established
that the active form of vitamin D3 directly activates one of the genes
(CST5) in the human colon cancer cell lines, increasing levels of the
cystatin D protein. Functionally, cystatin D was shown to inhibit the growth
of human colon cancer cells lines in vitro and also when they were
transplanted into mice.
Since reducing expression of cystatin D in human colon cancer cell lines
rendered them unresponsive to the suppressor effects of the active form of
vitamin D3, the authors concluded that the CST5 gene is a candidate tumor
suppressor gene and is responsible for a large proportion of the anticancer
effects of the active form of vitamin D3.
These data provide rationale for commencing clinical trials examining the
preventive and therapeutic potential of the active form of vitamin D3 in
colon cancer.
SOURCE: Journal of Clinical Investigation, July 6, 2009 |
