Cholesterol Control Genes
Reported July 10, 2009
(Ivanhoe Newswire) -- Twenty genes playing large roles in controlling
cholesterol within cells have been identified through several innovative
methods. These genes may also point the way to new risk factors for heart
"Some of the genes identified by us as regulators of cellular cholesterol in
future studies might turn out to be disease genes that contribute to
hypercholesterolemia in some cases," Heiko Runz of the University of
Heidelberg was quoted as saying. "Moreover, the strategy we used could open
a new avenue to identify risk factors for cardiovascular disease."
Researchers were in pursuit of new cholesterol-regulatory factors, and
started by looking at genes that showed a similar behavior pattern already
identified with cholesterol. RNA interference, a method used to identify
cellular behaviors. It led the team to a list of 20 genes they believe to be
relevant in maintaining cellular levels of cholesterol.
SOURCE: Cell Metabolism, July 8, 2009