Reported April 22, 2010
April 22, 2010 — Dietary intakes of folate and
vitamin B6 reduce the risk for mortality from stroke and any cardiovascular
disease in women and may reduce the risk for heart failure in men, according
to a study conducted in Japan.
The findings were reported online April 15 in Stroke by Renzhe Cui, MD, from
the Graduate School of Medicine at Osaka University, in Osaka, Japan, and
"This study is the first to show that high dietary intakes of folate and
vitamin B6 were associated with a reduced risk of heart failure mortality
for men," the authors note.
Data from 23,119 men and 35,611 women (aged 40 - 79 years) who completed
food frequency questionnaires as part of the Japan Collaborative Cohort
study were analyzed. At a median 14 years of follow-up, 986 participants
died from stroke, 424 died from coronary heart disease, and 2087 died from
any cardiovascular disease.
Participants' intake of folate, vitamin B6, and vitamin
B12 were classified into quintiles. Comparing the lowest vs the highest
quintiles for each nutrient, the researchers found that higher consumption
of folate and vitamin B6 was associated with significantly fewer deaths from
heart failure in men, and significantly fewer deaths from stroke, heart
disease, and any cardiovascular diseases in women. By contrast, vitamin B12
intake was not associated with reduced mortality risk.
The protective effects of folate and vitamin B6 remained significant after
adjustment for the presence of cardiovascular risk factors and also after
exclusion of supplement users (n = 7334) from the analysis.
The hazard ratios (HRs) of coronary heart disease for the highest vs the
lowest quintiles were 0.62 (95% confidence interval [CI], 0.42 - 0.89) for
folate, 0.51 (95% CI, 0.29 - 0.91) for vitamin B6, and 1.35 (95% CI, 0.80 -
2.27) for vitamin B12. The HRs of heart failure for the highest vs the
lowest quintiles were 0.76 (95% CI, 0.51 - 1.13) for folate, 0.60 (95% CI,
0.32 - 1.13) for vitamin B6, and 1.57 (95% CI, 0.90 - 2.73) for vitamin B12.
"Mechanisms for these observed associations may involve the effects of these
vitamin intakes on reduction of blood homocysteine concentrations," the
This study has received grant funding from the Ministry of Education,
Science, Sports and Culture of, Japan (Monbusho), Japanese Ministry of
Education, Culture, Sports, Science, and Technology. The study authors have
disclosed no relevant financial relationships.
Source : Medscape Medical News