(Ivanhoe Newswire) -- Researchers have identified a new source of
insulin-producing cells. Results of a new study show cells in the pancreas that
produce insulin -- called beta cells -- can form after birth or after injury
from another, unrelated kind of cell. The unrelated cells, called pancreatic
duct cells, can differentiate into the insulin-producing cells.
The finding contradicts widely-cited research published in 2004 that suggested
new beta cells could only come about through the division of existing beta
cells.
“This means that there is a population of pancreatic cells that can be
stimulated, either within the body or outside the body, to become new beta
cells, the cells that are lacking in diabetes,” lead researcher Susan
Bonner-Weir, Ph.D., a senior investigator in the Section on Islet
Transplantation and Cell Biology at the Joslin Diabetes Center and Associate
Professor of Medicine at Harvard Medical School.
In
type 1 diabetes, insulin-producing beta cells are destroyed by the immune
system, leading the pancreas to produce little or no insulin. The discovery
could lead to a new type of replacement therapy for type 1 diabetes patients.
Although transplantation of beta cells from human donors has helped patients
with type 1 diabetes get off insulin treatment, the results are only successful
for a few years.
SOURCE: Proceedings of the National Academy of Sciences, November 2008