LOS ANGELES (Ivanhoe Broadcast News) -- About 20
million people in the U.S. have diabetes. Up to 10
percent of these cases are type 1, where the pancreas
stops making insulin, and patients must rely on
injecting it to stay alive. Now, there are two new
breakthroughs: one that could prevent people from
getting the disease in the first place, and another that
could help diabetes patients make insulin on their own.
Diabetic Noel Wynn looks healthy, but if she isn’t
vigilant about her health, she could slip into a coma
and even die. “This body has to last,” Wynn says. “I am
going to do everything I can to prolong my life and
prevent anything.”
That’s what diabetes research centers on: giving
patients the longest, healthiest life possible. Now,
researchers are even trying to develop new ways to
prevent people from getting it.
Daniel Kaufman, Ph.D., an immunologist at UCLA in Los
Angeles, has recently developed a vaccine that could
prevent type 1 diabetes. The vaccine works by slowing
down the attack on the immune system and saving cells
that produce insulin in the pancreas. The vaccine worked
on mice, but now, the goal is to vaccinate humans.
Kaufman is particularly interested in identifying
children who are at risk of developing diabetes and
changing their immune responses to prevent the disease
from occurring.
Across the country, Luca Inverardi, M.D., a
transplantation immunologist at the University of Miami
Leonard M. Miller School of Medicine in Florida, hopes
to perfect a breakthrough procedure called an islet cell
transplant. He believes the procedure could make it so
diabetics are no longer dependent on the insulin
injections they currently use to stay alive. “Patients
will require a fraction of the insulin they needed
before the transplants,” Dr. Inverardi says. He’s run
tests on animals by implanting them with a biomechanical
mesh piece filled with islet cells from a donor. Dr.
Inverardi says the procedure is safer than simply
injecting the cells into a patient’s liver because the
patient won’t have to rely on drugs to suppress the
immune system. “This could really represent a major
advantage for patients,” he says.
If you would like more information, please contact:
Stuart Wolpert
Senior Media Relations Officer
University of California, Los Angeles
Los Angeles, CA
swolpert@support.ucla.edu