Reverse Kidney Failure: Cut Carbs?
Reported April 21, 2011
(Ivanhoe Newswire) -- Diabetics now have a new reason to cut back on sugars and
starches. A new study found that a low-carb diet might help reverse kidney
damage in people who have type 1 and type 2 diabetes.
For the first time, researchers from Mount Sinai School of Medicine have found
that the ketogenic diet, which is a specialized high-fat and low-carb diet, may
help reverse kidney failure. For the study, Charles Mobbs, Ph.D., Professor of
Neuroscience and Geriatrics and Palliative Care Medicine at Mount Sinai School
of Medicine, and his colleagues analyzed mice that were genetically predisposed
to have diabetes. The mice also developed kidney failure. Half of the mice were
put on the ketogenic diet, while the other half maintained a high-carb diet.
After eight weeks, kidney failure was reversed in the mice on the ketogenic
diet.
“Knowing how the ketogenic diet reverses nephropathy (kidney damage) will help
us identify a drug target and subsequent pharmacological interventions that
mimic the effect of the diet,” Dr. Mobbs was quoted as saying.
Researchers say since the diet comes with extreme requirements, it is not a
long-term solution in adults. However, they estimate that following the diet for
as little as a month may be enough to reset the gene expression and pathological
process that leads to failed kidneys.
The researchers also found a previously unreported panel of genes linked to
diabetes-related kidney failure, whose expression was reversed by the diet.
Dr. Mobbs believes the diet could also help treat other neurological diseases.
The National Institutes of Health and the Juvenile Diabetes Research Foundation
helped fund the study.
SOURCE: PLoS ONE, April 20, 2011
|