(Ivanhoe Newswire) -- In a new study that compared standard and more
intense glucose control in veterans with type 2 diabetes, researchers found a
more tightly controlled regimen didn't make a significant difference when it
came to cardiovascular problems.
One group of veterans received standard glucose control and another group
received therapy with the goal of keeping hemoglobin levels 1.5 percent lower
than in the standard group.
Intensive therapy did not delay cardiovascular events significantly compared to
standard therapy. There were also no significant differences between the two
groups when it came to death rates. In fact, the number of sudden deaths in the
intensive-therapy group was three-times that of the standard-therapy group, and
more people who received intensive therapy experienced severe adverse events.
Intensive therapy had no significant impact on a patient's progression to eye
problems like diabetic retinopathy or macular edema, or on a patient's
development of neuropathy.
"Intensive glycemic control earlier in the disease course may produce benefit,
especially if severe hypoglycemia is avoided," study authors wrote. "For now,
appropriate management of hypertension, dyslipidemia and other cardiovascular
risk factors appears to be the most effective approach to preventing
cardiovascular morbidity and mortality."
More than 60 percent of all patients with type 2 diabetes die of cardiovascular
disease, and even more have serious complications.
SOURCE: New England Journal of Medicine, 2009;360:129-139
