(Ivanhoe Newswire) -- Researchers have discovered 10 new gene variants
linked to blood sugar or insulin levels, five of which have been found to
increase an individual’s risk for type 2 diabetes.
The study involved data from more than 122,000 people of European descent. Most
of the variants linked to diabetes appear to work by affecting insulin secretion
and not insulin resistance. Researchers say this may mean diet, lifestyle and
obesity could impact insulin resistance more so than insulin secretion.
"The fact that not all genes involved with raising glucose levels increase
diabetes risk tells us that it's not the mere fact of raising glucose that's
important but rather how glucose is raised,” Jose Florez, M.D., Ph.D., of the
Massachusetts General Hospitals Diabetes Unit and the Center for Human Genetic
Research in Boston, Mass., and co-lead author of the study, was quoted as
saying. “It's one thing to increase glucose slightly within the normal range and
quite another to affect a pathway that eventually leads to progressive glucose
elevation, beta-cell failure or insulin resistance -- in other words type 2
diabetes.”
Dr. Florez says there’s still more work to be done; only 10 percent of the genes
that control glucose levels in non-diabetics have been identified. More
research, he says, may lead to better treatments for diabetes.
"Finding these new pathways can help us better understand how glucose is
regulated, distinguish between normal and pathological glucose variations and
develop potential new therapies for type 2 diabetes," Dr. Florez explained.
Source: Nature Genetics, published online January 2010