THURSDAY, Dec. 3 (HealthDay News) -- Women who have gestational diabetes
mellitus (GDM) or gestational impaired glucose tolerance (GIGT) are at increased
risk for developing metabolic syndrome after they deliver their infants,
according to a study published online Nov. 19 in the Journal of Clinical
Endocrinology & Metabolism.
Ravi Retnakaran M.D., of Leadership Sinai Centre for Diabetes in Toronto, and
colleagues analyzed data on 487 women who underwent oral glucose tolerance
testing during pregnancy and metabolic evaluation three months after delivery.
The women were placed in three groups based on the glucose testing in pregnancy:
1) those with GDM, 2) those with GIGT, and those with normal glucose tolerance (NGT).
The primary outcome was metabolic syndrome, as defined by International Diabetes
Federation (IDF) and the American Heart Association/National Heart Lung and
Blood Institute (AHA/NHLBI) criteria.
Three months after delivery, the researchers found that the prevalence of
metabolic syndrome was 10 percent in the NGT group, 17.6 percent in the GIGT
group, and 20 percent in the GDM group by IDF criteria. Similar results were
recorded for AHA/NHLBI criteria: NGT, 8.9 percent; GIGT, 15.4 percent; and GDM,
16.8 percent. In regression analysis, both GDM and GIGT were predictors of
postpartum metabolic syndrome (odds ratios, 2.05 and 2.16, respectively).
"Both GDM and mild glucose intolerance in pregnancy predict an increased
likelihood of metabolic syndrome at three-months postpartum, supporting the
concept that women with gestational dysglycemia may have an underlying latent
metabolic syndrome," the authors write.
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