SAN ANTONIO, TX --Treatment of low levels of vitamin D in women with
early-stage breast cancer appears to reduce fatigue and muscle pain associated
with aromatase inhibitor therapy, researchers reported here at the 30th San
Antonio Breast Cancer Symposium (SABCS).
The preliminary results involving 40 women out of planned enrollment of 60 women
were presented in a poster presentation here on December 16 by Qaram Khan, MD,
Assistant Professor of Hematology/Oncology, University of Kansas Medical Center,
Kansas City, Kansas.
Although the study showed that vitamin D insufficiency was already present in
75% of women at the start of adjuvant aromatase inhibitor therapy, when vitamin
D supplementation was added to treatment, there was a decrease in fatigue and
muscle pain, Dr. Khan reported.
For the 16-week study, postmenopausal women with early-stage invasive breast
cancer were started on the aromatase inhibitor letrozole in addition to 1,200
mg/day of calcium and 600 IU/day of vitamin D. Vitamin D levels were recorded at
baseline and at weeks 4, 10, and 16.
Four weeks later, the women who still had vitamin D serum levels of less than 40
ng/mL were given 50,000 units of oral vitamin D once every week for 12 weeks.
At the start of the study, women were assessed for fatigue and musculoskeletal
pain. The fatigue scores on the Brief Fatigue Inventory rose from about 1.7 to
about 2.5 during the first 4 weeks of treatment, and then decreased to near
baseline levels after beginning the extra supplementation. Similarly, muscular
pain remained constant from baseline to 4 weeks and then decreased dramatically
from 0.4 to 0.2 on the Health Assessment Questionnaire.
At the start of the study 17 of 40 women were found to be deficient in vitamin D
(serum levels <20 ng/mL); 32 of the 40 women had insufficient levels of vitamin
D (<36 ng/mL); and 36 of the 40 women had less than optimal levels of vitamin D
for breast health (<40 ng/mL).
After week 16, there were no women among the 36 who finished the trial who were
deficient in vitamin D. One woman was judged to have insufficient levels of
vitamin D, and two of the 36 women had less serum vitamin D than is optimal for
breast health.
Dr. Khan said a randomized, controlled trial is being planned to confirm the
pilot study results. He said that supplementation appears safe and effective.
