ORLANDO, Fla. (Ivanhoe Newswire) -- A drug approved for osteoporosis
prevention and treatment may also prevent breast and other types of cancer.
A study at the University of California at San Diego found post-menopausal
women who took the drug raloxifene (Evista) were 55 percent less likely to
develop invasive, estrogen-receptor (ER) positive breast cancer compared
with women who did not take the drug. The drug reduced this risk for at
least 8 years regardless of age, prior hormone use or baseline breast cancer
risk.
“This is great because a lot of women have bone issues, and may be at a high
risk for getting an invasive breast cancer,” Dr. Black said. “This medicine
is a safe medicine that can prevent breast cancer.”
Raloxifene is a selective estrogen receptor modulator (SERM), which means it
has estrogen-like effects on tissues like bone, but anti-estrogen effects on
tissues like breast tissue. Most post-menopausal women with breast cancer
have invasive, ER positive breast cancer. When breast cancer is invasive, it
has started to break through normal breast tissue barriers and invade
surrounding areas. ER positive, or hormone responsive, means the breast
cancer grows when it comes in contact with estrogen.
“We now have medicines, such as Evista, that can sit on that estrogen
receptor and block that receptor so that estrogen cannot get on [it],”
Dalliah Mashon Black, M.D., a breast surgeon at the Hoffberger Breast Center
at Mercy Medical Center in Baltimore, who is not associated with the study,
told Ivanhoe. “That, in turn, kills the cancer cells.”
The study was conducted as a follow-up to the Raloxifene Use for the Heart
Trial (RUTH), the world’s largest study of women and heart disease to date.
The trial found raloxifene did not protect against heart disease, but did
reduce the risk of invasive breast cancer by 44 percent.
According to the National Cancer Institute, 182,460 new cases of breast
cancer in women will be diagnosed in 2008.
SOURCE: Journal of the National Cancer Institute, 2008; published online
June 10th