Unexplained rapid weight loss in older people could be a sign of underlying disease and can be linked with increased risk of falls and fractures, as well as a poorer long-term prognosis. The understanding of factors that could contribute to rapid weight loss remains poor, with current treatments including correcting suboptimal dietary and physical activity behaviors. New … [Read more...]
Weight Management News
New Weight Loss Medication may help Lower Blood Pressure in Adults with Obesity
The new weight loss medication tirzepatide significantly lowered the systolic blood pressure (the top number in a blood pressure reading) for nearly 500 adults with obesity who took the medication for about eight months, according to new research published today in Hypertension, an American Heart Association journal. Systolic blood pressure, or the top number in the blood … [Read more...]
Main Regulator for the Body’s ‘Oven’ Discovered
Obesity is defined as a pathological increase in white fat, and has become a major problem worldwide, with a greatly increased risk of cardiovascular diseases such as heart attack and stroke. "Exercise and dieting are not enough to effectively and permanently shed the pounds," says corresponding author Prof. Alexander Pfeifer, Director of the Institute of Pharmacology and … [Read more...]
However, Adults Hardly have any Brown Fat, and it can be Found Mainly in Young and Slim People.
"We therefore asked how brown fat mass can be increased while simultaneously reducing bad white fat," says Bonn postdoctoral researcher and first author Dr. Laia Reverte-Salisa. Together with researchers from the University Medical Center Hamburg-Eppendorf, Helmholtz Munich and the University of Toulouse-Paul Sabatier, the Bonn team investigated the cAMP signaling pathway in … [Read more...]
Main Regulator for the Body`s ‘oven’ Discovered
Brown fat cells convert energy into heat -- a key to eliminating unwanted fat deposits. In addition, they also protect against cardiovascular diseases. Researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Area "Life & Health" at the University of Bonn have now identified the protein EPAC1 as a new pharmacological target to increase brown … [Read more...]
People With Obesity Burn Less Energy During Day
Weight influences how and when bodies burn energy, new research indicates. An Oregon Health & Science University study published in the journal Obesity found people who have a healthy weight use more energy during the day, when most people are active and eat, while those who have obesity spend more energy during the night, when most people sleep. The study also found … [Read more...]
Obesity Leads to a Complex Inflammatory Response Inside Fat Tissue
Fat tissue, for as much as it's been vilified, is an incredibly complex and essential bodily organ involved in energy storage and hormone production, among other functions. Yet, modern lifestyles have led to a worldwide epidemic of obesity, and a corresponding increase in related conditions like type 2 diabetes and cardiovascular disease. Researchers are attempting to … [Read more...]
Can’t Stop Binging on Fries and BBQ?
People overeat and become overweight for a variety of reasons. The fact that flavorful high-calorie food is often available nearly everywhere at any time doesn't help. Buck researchers have determined for the first time why certain chemicals in cooked or processed foods, called advanced glycation end products, or AGEs, increase hunger and test our willpower or ability to make … [Read more...]
Almonds as Part of a Healthy Weight Loss Diet
When it comes to weight loss, nuts can get a bad rap -- while they're high in protein, they're also high in fats, and this often deters those looking to shed a few kilos. But new research from the University of South Australia shows that you can eat almonds and lose weight too. In the largest study of its kind, researchers found that including almonds in an energy restricted … [Read more...]
Both High-Protein and Normal-Protein Diets are Effective For T2D Management
Published in the journal Obesity, 106 adults with T2D were randomly assigned to either the high-protein or normal-protein diet for 52 weeks. Both diets were energy-restricted. The high-protein diet included recommendations to include lean beef in the diet, while the normal-protein diet instructed participants to refrain from eating any red meats. The team of researchers found … [Read more...]
A new Breakthrough in Obesity Research may Allow You to Lose Fat While Eating all You Want
The complex balance between food intake and energy expenditure is overseen by the hypothalamus in the brain. While it has been known that the neurons in the lateral hypothalamus are connected to fat tissue and are involved in fat metabolism, their exact role in fat metabolism regulation has remained a mystery. The researchers discovered a cluster of neurons in the hypothalamus … [Read more...]
Fewer Teens Now Perceive Themselves as Overweight
A study involving more than 745,000 adolescents from 41 countries across Europe and North America identified an increase in the amount of teenagers who underestimate their body weight. Tracking data from 2002 to 2018, the peer-reviewed findings, published today in Child and Adolescent Obesity, demonstrate a noticeable decrease in those who overestimate their weight … [Read more...]
One Third of Normal-Weight Individuals are obese, according to study based on body fat percentage
The study -- the largest of its kind ever conducted in Israel -- was led by Prof. Yftach Gepner and PhD student Yair Lahav, in collaboration with Aviv Kfir. It and was based on data from the Yair Lahav Nutrition Center in Tel Aviv. The paper was published in Frontiers in Nutrition. Prof. Gepner: "Israel is a leader in childhood obesity and more than 60% of the country's … [Read more...]
Diet Tracking: How Much is Enough to Lose Weight?
Keeping track of everything you eat and drink in a day is a tedious task that is tough to keep up with over time. Unfortunately, dutiful tracking is a vital component for successful weight loss, however, a new study in Obesity finds that perfect tracking is not needed to achieve significant weight loss. Researchers from UConn, the University of Florida, and the University of … [Read more...]
Researchers Design an Innovative Strategy to Fight Obesity Through Gene Therapy
A scientific team from the University of Barcelona and the CIBERobn has designed a strategy to fight obesity and diabetes in mice through ex vivo gene therapy which consists of implanting cells that have been manipulated and transformed in order to treat a disease. This is the first study to apply the ex vivo gene therapy technique to generate and implant cells that express the … [Read more...]
People with Obesity due to Genetic Predisposition have Lower Risk of Cardiovascular Disease
There has been a global increase in the incidence of overweight and obesity over the past few years. Almost one third of the world's population now liveswith overweight or obesity. "The figure is alarming since it is well-established that a high BMI in middle-age increases the risk of developing cardiovascular disease and other conditions," says Ida Karlsson, assistant … [Read more...]
Obesity Turning Arthritic Joint Cells into Pro-inflammation “Bad Apples”
In a new study published in Clinical and Translational Medicine today, researchers from the University of Birmingham have found that specific cells in the joint lining tissue (synovium) of patients with osteoarthritis are being changed due to factors associated with obesity. Previous research has shown that fat tissue that has been metabolically altered by obesity releases … [Read more...]
Youth Overweight a Risk Factor for Blood Clots as Adult
The association between obesity and blood clots is already established. However, to date it has been unclear how much influence a raised BMI in childhood and puberty exerts. The purpose of the study was to clarify the links between BMI in early life and subsequent thrombi. Thrombi usually arise in the legs, often starting in a blood vessel in the calf. Swelling, pain and … [Read more...]
Rhythmic Eating Pattern Preserves Fruit Fly Muscle Function Under Obese Conditions
Obese fruit flies are the experimental subjects in a Nature Communications study of the causes of muscle function decline due to obesity. In humans, skeletal muscle plays a crucial role in metabolism, and muscle dysfunction due to human obesity can lead to insulin resistance and reduced energy levels. Interestingly, studies in various animal models have shown that … [Read more...]
Study Compares Adverse Events After Two Types of Bariatric Surgery in Adolescents
Adolescents who underwent sleeve gastrectomy, a type of weight-loss surgery that involves removing part of the stomach, were less likely to go the emergency room or be admitted to the hospital in the five years after their operations than those who had their stomachs divided into pouches through gastric bypass surgery, according to new research. Rates of complications, death … [Read more...]
Scientists Redefine Obesity with Discovery of Two Major Subtypes
A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication. The findings, published today in the journal Nature Metabolism, offer a more nuanced understanding of obesity than current definitions and may one day inform … [Read more...]
Insufficient Sleep in Teenagers is Associated with Overweight and Obesity
Adolescents who sleep less than eight hours a night are more likely to be overweight or obese compared to their peers with sufficient sleep, according to research presented at ESC Congress 2022. Shorter sleepers were also more likely to have a combination of other unhealthy characteristics including excess fat around the middle, elevated blood pressure, and abnormal blood lipid … [Read more...]
Sleep is Linked to Heart Health
Sleep duration is now considered an essential component for ideal heart and brain health. Life's Essential 8™ cardiovascular health score replaces Life's Simple 7™, according to a new Presidential Advisory, Life's Essential 8 -- Updating and Enhancing the American Heart Association's Construct on Cardiovascular Health, published today in Circulation, the Association's flagship, … [Read more...]
How High-Intensity Interval Training can Reshape Metabolism
Scientists have shed new light on the effects that high-intensity interval training (HIIT) has on human skeletal muscle, according to a study in men published today in eLife. The findings suggest that HIIT boosts the amount of proteins in skeletal muscle that are essential for energy metabolism and muscle contraction, and chemically alters key metabolic proteins. These … [Read more...]
Excessive Sports Training May Have Negative Effects on Mood
To build fitness, athletes must apply stress to the body, and then through recovery, the body adapts and is able to accommodate greater stress in the next round of training. Maintaining reasonable amounts of stress and promoting recovery is essential to ameliorate the performance of athletes, as well as to prevent injuries and problems associated with … [Read more...]
Diet Type can Increase Potentially Harmful Gas in The Gut
Published in Clinical Nutrition, researchers from the University of Minnesota Medical School looked at colonic hydrogen sulfide -- a toxic gas in the body that smells like rotten eggs -- production in people in response to animal- and plant-based diet interventions. "Although the role of hydrogen sulfide has long been a subject of great interest in the pathogenesis of … [Read more...]
Diets High in Fiber Associated with Less Antibiotic Resistance in Gut Bacteria
Microbes that have resistance to various commonly used antibiotics such as tetracycline and aminoglycoside are a significant source of risk for people worldwide, with the widely held expectation that the problem of antimicrobial resistance (AMR) -- the term that refers to bacteria, viruses, and fungi that are resistant to antibiotics -- is likely to worsen throughout the coming … [Read more...]
Scientists Study Links Between Obesity, Age and Body Chemistry
According to Centers for Disease Control and Prevention (CDC) data collected in 2017-18, more than 42% of U.S. adults and 19% of U.S. youths are obese. Three Clemson researchers and colleagues from the Emory University School of Medicine studied male mice that lacked the Cyp2b enzyme and how the lack of the enzyme affected the mice's metabolism. William Baldwin, a … [Read more...]
Researchers Identify Potential New Treatment for Metabolic Syndrome
"In 2016, our lab discovered a hormone called asprosin, which stimulates appetite and increases blood glucose levels by acting on the hypothalamus and the liver," explained Atul Chopra, MD, PhD, senior author on the study, Investigator at the Harrington Discovery Institute and Associate Director of the Oxford-Harrington Rare Disease Center, Attending Medical Geneticist at UH, … [Read more...]
High Cardiovascular Risk is Associated with Symptoms of Depression
Cardiovascular disease and depression are thought to be closely related due to similar risk factors, including inflammation and oxidative stress. Although it has been shown that depression could be a risk factor for developing cardiovascular disease, studies analyzing the potential impact of cardiovascular health on developing depression are scarce. In the new study, the … [Read more...]
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