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Breast Cancer Risk Factors Differ Among Ethnic
Groups
Reported April 28, 2010
(Ivanhoe Newswire) -- Breast cancer occurs more frequently in certain
ethnic and racial groups, but the reasons behind these differences are not
fully understood. For example, factors known to increase the risk of breast
cancer among white women have less influence in Hispanic women.
Lisa Hines, ScD, of the University of Colorado at Colorado Springs, and
colleagues conducted a study that considered how established breast cancer
risk factors—including reproductive history, family history of breast
cancer, menstrual history, hormone use, alcohol consumption, physical
activity, height, and body mass index—might be involved in explaining some
of the observed differences in the occurrence of breast cancer among racial
and ethnic groups. They studied breast cancer among women from the Southwest
United States who were enrolled in the population-based, case-control
4-Corners Breast Cancer Study, which investigated factors that contribute to
the difference in breast cancer incidence rates observed between Hispanic
and non-Hispanic white women.
In this study, the researchers found that 62 to 75 percent of breast cancer
cases among non-Hispanic white women were attributed to known breast cancer
risk factors, compared with only 7 to 36 percent of cases among Hispanic
women. Hispanic women were more likely to have characteristics associated
with lower breast cancer risk, such as earlier age at first childbirth,
having more children, shorter height, less hormone use, and less alcohol
consumption.
Among premenopausal women, taller height and family history of breast cancer
were associated with increased risk in non-Hispanic white women, but not
among Hispanic women. Among postmenopausal women, certain breast cancer risk
factors in non-Hispanic whites, such as recent hormone therapy use and
younger age at menarche, had little or no associations with breast cancer in
Hispanics.
These findings suggest that many of the risk factors studied to date explain
fewer of the breast cancer cases that arise in Hispanic women. "These
differences are likely to contribute to disparities in breast cancer
incidence rates, and could potentially reflect differences in breast cancer
development among these ethnic groups," Dr. Hines was quoted as saying. For
example, ethnic differences in genetic and environmental or lifestyle
factors may affect individuals' susceptibility to the development of breast
cancer.
SOURCE: Cancer, online, April 26, 2010 |