There is little evidence to show herbal remedies purported to relieve symptoms
of menopause actually work, according to a new study.
A growing number of women have turned to black cohosh, evening primrose oil and
other natural remedies in recent years to treat hot flashes, irritability and
other related problems. Evidence that hormone replacement therapy is associated
with a risk of heart disease, stroke and other cardio-vascular problems also may
have increased the number of women looking for alternatives to prescription
treatments for menopausal symptoms.
But evidence demonstrating the effectiveness of these remedies is often
under-researched, weak or even "non-existent," according to a new report.
The report appears in this month's edition Drug and Therapeutics Bulletin,
published by the British Medical Journal.
"A lot of treatments have become established with time in terms of people trying
them out. But if you were looking for cast-iron evidence for lots of treatments
you wouldn't be able to find it," said Ike Iheanacho, editor of the bulletin.
The report evaluates studies that have been conducted on the effectiveness of
black cohosh, red clover and other non-prescription treatments for symptoms of
menopause. Some herbs, such as ginseng, are used to help a variety of
conditions, and also touted by health-care groups and some manufacturers as ways
to ease symptoms associated with menopause as well as premenstrual syndrome.
But much of the supporting evidence is contradictory or weak, according to the
bulletin.
Black cohosh: The report revealed contradictory evidence. Several studies found
that women who took black cohosh over a period of time reported no major
difference in hot flashes or other menopausal symptoms compared with women given
placebo. Other studies found the herbal remedy did provide some relief to some
women. The product has also been associated with increased risk of liver
toxicity and was subject to a Health Canada warning in 2006 as a result.
Red clover: A review of 30 trials found no major difference in menopausal
symptoms among women who took red clover extracts compared with placebo. Red
clover contains phytoestrogens, which are believed to deliver estrogen-like
effects, but it's not clear how this occurs or what the benefits are, the report
said.
Dong quai: It's a plant popular in traditional Chinese medicine that has been
used to help women in a variety of ways, including recovery from childbirth and
relief of menopausal symptoms. One study found no difference between dong quai
and placebo in reducing hot flashes. Another found dong quai combined with
chamomile resulted in a decrease of hot flashes compared with placebo.
Evening primrose oil: A review of one study found no difference in menopausal
symptoms in women who took the herbal remedy compared with women who took
placebo.
Ginseng: A review of two studies found women who took it for menopausal symptoms
experienced no significant benefit compared with those who took placebo.
That's not to say herbal remedies have no benefit, Dr. Iheanacho said. But as
more consumers turn to natural remedies, it's important to provide better, more
credible evidence on how well these therapies work, what the potential risks are
and who they are best suited for, he said.
In many countries, including Canada, natural health products can be approved for
sale as long as the manufacturer can show they have been used as a herbal remedy
for decades.
As a result, some companies may be reluctant to invest the kind of cash
necessary to finance more extensive and potentially conclusive studies,
especially if it won't affect their ability to market their product, he said.
Health Canada created a bureau several years ago to license natural health
products and regulate their sale. But it's been overwhelmed with applications,
meaning there are still many unlicensed natural health products on the market.
Some health experts have criticized Health Canada for not requiring more
conclusive trials, such as those conducted by drug companies, to provide better
proof of a natural product's safety and effectiveness.
However, one naturopathic doctor said herbs are much different than drugs and
shouldn't necessarily be subject to the same type of standards. It may be better
to track their use and any reported side effects, in addition to doing research,
to get a better sense of their effectiveness, said Kieran Cooley, assistant
professor at the Canadian College of Naturopathic Medicine in Toronto.
He said that type of initiative will require improved government funding,
particularly considering how many Canadians are now using natural therapies. "As
we start collecting better data, we get a better understanding."