TORONTO, April 14 /PRNewswire-USNewswire/ -- Researchers have identified
a gene that appears to increase a person's risk of developing late-onset
Alzheimer's disease, the most common type of Alzheimer's disease. The research
is presented as part of the late-breaking science program at the American
Academy of Neurology's 62nd Annual Meeting in Toronto, April 10 – 17, 2010. The
gene, abbreviated MTHFD1L, is located on chromosome six.
"Only recently have common variants in genes other than APOE been convincingly
shown to be associated with a person's risk of developing late-onset Alzheimer's
disease," said senior author Margaret Pericak-Vance, PhD, Director of the
University of Miami Miller School of Medicine's John P. Hussman Institute for
Human Genomics in Miami, Florida.
Researchers looked at gene variation throughout the human genomes of 2,269
people with late-onset Alzheimer's disease and 3,107 people without the disease
through what's known as a genome-wide association study. Such studies involve
looking at stretches of DNA to identify small differences in the genetic
sequence between people with and without Alzheimer's disease.
The study found that individuals with a particular variation in the gene MTHFD1L
may be almost twice as likely to develop Alzheimer's disease as those people
without the variation. "We are hopeful our identification of MTHFD1L as a risk
gene for Alzheimer's disease will help us to better understand how this disease
develops and potentially serve as a marker for people who may be at increased
risk," said Adam Naj, PhD, with the University of Miami Miller School of
Medicine's John P. Hussman Institute for Human Genomics in Miami and the first
author of the abstract reporting the discovery.
"Identifying this gene is important because the gene is known to be involved in
influencing the body's levels of homocysteine, and high levels of homocysteine
are a strong risk factor for late-onset Alzheimer's disease," said Pericak-Vance.
"In addition, variations of the MTHFD1L gene have been reported to possibly
increase the risk of coronary artery disease. Since the function of blood
vessels in the brain may affect Alzheimer's disease, this finding may also help
us understand how homocysteine levels and blood vessel function in the brain
affect Alzheimer's."
The study was supported by the National Institutes of Health and the National
Institute on Aging. The research team includes collaborators Jonathan Haines,
PhD, from Vanderbilt University Medical Center and Joseph D. Buxbaum, PhD, with
Mount Sinai School of Medicine.
Source : prnewswire.com
