Milk, Blood of Pregnant, Lactating Women have Abzymes; Normal Men, Women
don't
(Russian Academy Science-December 17, 2003)
"In human milk, we previously
found catalytic antibodies (abzymes)
catalyzing hydrolysis of DNA, RNA, NMP, NDP, and NTP, and also
phosphorylation of proteins and lipids. In the present study, we have
analyzed nuclease activities of antibodies in blood of women during
pregnancy and lactation," scientists in Russia report.
"Blood of healthy male and
female volunteers lacked catalytically active antibodies, whereas antibodies
from blood of pregnant women hydrolyzed DNA and RNA and their relative
activity varied over a wide range. Relative blood abzyme activities
significantly increased after delivery and at the beginning of lactation.
"The highest abzyme activity
was observed in blood of parturient women. Although the dynamics of changes
in antibody DNase activity during pregnancy was rather individual for each
woman, there was a common trend in the increase in antibody activity in the
first and/or third trimester of the pregnancy," wrote V.N. Buneva and
coauthors from the Russian Academy of Science.
The researchers concluded:
"The DNase activity of IgG and IgM from blood of healthy pregnant women was
4-5 times less than that from pregnant women with pronounced autoimmune-thyroiditis."
Buneva and colleagues
published their study in Biochemistry - Moscow (Dynamics of antibody
nuclease activity in blood of women during pregnancy and lactation.
Biochemistry (Mosc), 2003;68(8):890-900).
For more information, contact
G.A. Nevinsky, Russian Academy Science, Siberian Branch, Novosibirsk
Bioorganic Chemical Institute, Ul Lavrentieva 8, Novosibirsk 6300090,
Russia.
The information in this
article comes under the major subject areas of Human Milk, Abzymes,
Hematology, Proteomics, Immunology, Endocrinology, Obstetrics, Lactation,
and Women's Health. This article was prepared by Biotech Week editors from
staff and other reports.
©Copyright 2003, Biotech
Week via NewsRx.com & NewsRx.net
This story has been adapted from a news
release issued by NewsRx.com & NewsRx.net