New classes of antibacterial oxazolidinones reported

(Antimicrobials-January 19, 2004)

Researchers report new classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains in a recent issue of Bioorganic and Medicinal Chemistry Letters.

"Exploration of the structure-activity relationships of the traditional C-5 acetamidomethyl side chain of the oxazolidonone antibacterials has yielded new, potent series of compounds of which the first examples, the O-linked iosoxazoles are described in detail, leading to the selection of the pre-clinical candidate AZD2563," wrote Michael B. Gravestock and collaborators at AstraZeneca in the U.S. and U.K.

Gravestock and his colleagues published their study in Bioorganic and Medicinal Chemistry Letters (New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains. Bioorg Medicinal Chem Letter, 2003;13(23):4179-4186).

For additional information, contact Michael B. Gravestock, AstraZeneca R & D Boston, Infection Discovery, 35 Gatehouse Park, Waltham, MA 02451, USA.

The information in this article comes under the major subject areas of Antimicrobials, Anti-Infectives, Pharmaceutical and Drug Development, Bacteriology, and Proteomics. This article was prepared by Health & Medicine Week editors from staff and other reports.