Steroids Boost Joint Health in RA
Reported January 25, 2007
(Ivanhoe Newswire) — Taking low-dose steroids in the early stages of rheumatoid arthritis (RA) is probably a good idea.
Researchers who looked at 15 clinical trials conclude adding steroid therapy to standard rheumatoid arthritis drugs in the first two years after diagnosis can inhibit the progression of the disease.
The investigators explain many people with rheumatoid arthritis are given the drugs, also known as glucocorticoids, when first diagnosed with the condition to help with inflammation and other symptoms while longer-acting rheumatoid arthritis drugs have a chance to start working. However, because steroids have been linked to cardiovascular disease and bone mineral density problems, many doctors to forego these medications for rheumatoid arthritis patients or prescribe them at the lowest-possible dose for the shortest possible time.
Study authors suggest that level of caution may be unwarranted. While noting concerns remain regarding the long-term use of steroids, the authors write, “Even in the most conservative estimate, the evidence that glucocorticoids given in addition to standard therapy can significantly reduce the rate of erosion progression in rheumatoid arthritis is convincing.”
They write people who have had RA for less than two years would certainly benefit from the treatment without risking undue side effects, and the benefits may also extend to those who have been suffering with the condition for up to four years.
SOURCE: Cochrane Database of Systematic Reviews, published online Jan. 23, 2007