Chori-Bar: a Low Calorie, Food Supplement to Restore Metabolic Balance

Scientists at Children's Hospital Oakland Research Institute's (CHORI) Nutrition & Metabolism Center, led by National Medal of Science winner Bruce N. Ames, PhD, have developed a low-calorie fruit-based high fiber vitamin and mineral nutrition bar called the "CHORI-bar" .


The CHORI-bar combines aspects of the Mediterranean diet with the most biologically active form of folate (5-methyl-tetrahydrofolate). The latter is expected to bypass the need for high levels of folate required to keep homocysteine at a healthy level in individuals with the TT MTHFR polymorphism, which is present in half the U.S. population. 

The current bar has 36 ingredients and 107 calories. The bar is dense and very chewy, and the flavors - white chocolate blueberry or fruit cinnamon - is subtle, and not too sweet.

The bar is claimed to:
  • Improve biological indicators (increased HDL-c and glutathione, lowered homocysteine) linked to risk of cardiovascular disease, cognitive decline, and associated decline in anti-oxidant defenses. Glutathione is an antioxidant, preventing damage to important cellular components caused by reactive oxygen species such as free radicals and peroxides. A higher value of  HDL- c is beneficial because it protects from the development and progression of atherosclerotic disease. The lower your HDL-C (1 milligram HDL-C per 1 deciliter of blood), the higher your risk. Studies have shown that for every 1-mg/dL rise in HDL-C (1 milligram HDL-C per 1 deciliter of blood), the risk for developing cardiovascular disease decreases by 2% to 3%.  As HDL-C in blood penetrates atherosclerotic plaque in the vessel wall, it mobilizes and binds cholesterol and transports it back to the liver for elimination through the gastrointestinal tract. 

  • Chori-Bar: a Low Calorie, Food Supplement to Restore Metabolic BalanceHelp restore optimal nutritional balance in people eating poor diets. Food components such as certain soluble fibers and polyphenols,  benefit gut health but are deficient in typical Western diet, have been included in the bar along with a number of other ingredients, all aimed at helping to restore optimal nutrition.

  • Help develop healthier eating habits. All those who are over weight  tend to avoid taking healthy meals missing out on essential nutrients needed for growth and maintenance. 

  • Raise  glutathione level: - Glutathione is the principal regulator of the cellular redox environment, and is important for preventing oxidative stress. Glutathione declines with age and is low in many diseases. Few drugs and only high doses of certain food constituents have been reported to raise glutathione, but only 2-weeks consumption of the bar was required.

The CHORI-bar will appear in the August 2012 FASEB Journal (the Journal of the Federation of American Societies for Experimental Biology), but the creators of the CHORI-bar have made public some of the details involved in the test.  



Dated 22 May 2012


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