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Fibromyalgia
What
is Fibromyalgia?
The word fibromyalgia
literally means "pain of the fibrous tissue (ligaments and tendons) and
muscles." Fibromyalgia is a chronic,
widespread musculoskeletal pain syndrome with tender points at
multiple sites affecting the fibrous connective tissue and muscles. Chronic as
it does not get better in three months or lesser time. Widespread in the sense
that it is not limited to the neck or shoulder. Very often the pain is
experienced in all the four limbs as well as the neck, chest wall and the back. The
pain affects muscles and joints as well as the ligaments, tendons, and skin.
Syndrome for it is made up of a combination of many symptoms, such as pain,
fatigue, sleeping problem, tingling and headaches.
It
differs from arthritis in a way that, FM does not cause pain or swelling in the
joints. Rather, it produces pain in the soft tissues located around joints and
in skin and organs throughout the body.
It
can be disabling and often accompanies other types of arthritis,
particularly RA and systemic lupus. Fibromyalgia affects mostly women, causing
fatigue, sleep disturbances, depression and widespread pain in muscles and
tendons, particularly in the neck, spine, shoulders and hips. While it is not
life-threatening, the extreme fatigue and pain can lead to disability
and muscle weakness from
lack of activity.
RISK
FACTORS
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Being a
woman.
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Injury, trauma or
major surgery.
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Physical, sexual or
emotional abuse.
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Stress.
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Sleep deprivation.
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Genetic
predisposition.
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Fibromyalgia pain is not in the
joints, but in the muscles, ligaments and tendons. It may be triggered by an
infection, a physical trauma from
an accident or surgery, or an emotional
trauma from physical, sexual or other abuse which might affect the
brain and central nervous system which in turn produce the condition that we
know as fibromyalgia. A research conducted by Stuart Donaldson, Ph.D.; Mary Lee Esty,
Ph.D.; and Len Ochs, Ph.D., suggests that FM may
actually be a "CNS Myalgia" (central
nervous system myalgia) caused by a
traumatic brain injury which results in abnormalities in the functioning
of the brain and central nervous system.1
Heredity:
There is already evidence of a strong familial pattern in many cases of FM, with
fibromyalgia often following the female side of the family.
The patients show low Hypoglycemic effect of
insulin. Obviously they must be in pre diabetic phase an outcome of Pituitary
Hypothalamic- Insulin like factors axis disturbances.
It
is also connected with abnormal levels of
substance P, which transports pain messages; a growth hormone serotonin,
which helps regulate sleep, mood and pain perception. The core problem is immune
system dysfunction resulting from an immune system overload.
Symptoms
associated with Fibromyalgia:
FM has
few symptoms that are outwardly visible, it has been nicknamed "the
invisible disability" or the "irritable everything" syndrome.
Besides, its symptoms are common to various other disorders,
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Its primary symptoms
are generalized musculoskeletal
pain in at least three specific sites persisting for at least
three months and reproducible tenderness in at least six specific points
throughout the body. Pain can vary in severity from day to day and change
location, becoming more severe in parts of the body that are used the most
(i.e., neck, shoulders, and feet).
-
Irritable
bowel problems which are a combination of digestive
disturbances, abdominal pain, and bloating are quite common with FM as are
constipation and/or diarrhea. Irritable bladder symptoms are experienced by
about half of FM patients.
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SYMPTOMS OF
FIBROMYALGIA
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Pain 11 of 18
specific tinder points.
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Muscle aches all
over the body.
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Chronic fatigue.
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Insomnia or other
sleep disorders.
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Depression and
anxiety.
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Irritable bowel
syndrome.
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Tension headache
and migraine headache.
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Chronic
Fatigue syndrome (CFS) also seems to be closely related
with Fibromyalgia. The fatigue of FM also varies from person to person
ranging from a mild, tired feeling to the exhaustion of a flu-like illness.
FM is not physically crippling nor does it interfere with a person's
expected life span.
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Some
patients report pain and numbness in their arms and legs. Also known as "paresthesia",
the sensation can be described as prickling or burning.
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Stiffness:
Body stiffness is usually most apparent upon awakening and after prolonged
periods of sitting or standing in one position. It may also coincide with
changes in relative humidity.
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Increased
Headaches Or Facial Pain: Head/facial pain
is frequently a result of extremely stiff or tender neck/shoulder muscles which
refer pain upwards. It can also accompany temporomandibular
joint (TMJ) dysfunction, a condition which occurs in an estimated one-third of
those with FM and which affects the jaw joints and surrounding muscles.
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Sleep
Disturbances: Despite sufficient amounts of sleep, FM patients may
awaken feeling unrefreshed, as if they have barely
slept. Alternatively, they often have trouble falling asleep or staying asleep.
The reasons for the non-restorative sleep and other sleep difficulties of
fibromyalgia are unknown although early FM research in sleep labs documented
disruptions in the deep (delta) sleep of some patients.
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Difficulty
concentrating, "spaciness" or
"fibro-fog", memory lapses,
difficulty thinking of words/names, and feeling overwhelmed when engaged in
multiple tasks.
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Women with FM may have more painful
menstrual periods or experience a worsening of their FM symptoms
during this time. Conditions such as vulvar vestibulitis
or vulvodynia, characterized by a painful vulvar
region and painful sexual intercourse, may also develop in women.
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Shallow breathing
and postural problems might become obvious in patients involved in
activities involving continuous, forward body posture (i.e., typing, sitting at
a desk, working on an assembly line, etc.). They may
also develop a condition known as costochondralgia
(also referred to as costochondritis) which causes
muscle pain where the ribs meet the chest bone and is frequently mistaken for
heart disease.
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Leg Sensations:
Some FM patients may develop a neurological disorder known as "restless
legs syndrome" (RLS) which involves a "creepy crawly"
sensation in the legs and an irresistible urge to move the legs particularly
when at rest or when lying down. The syndrome may also involve periodic limb
movements during sleep (PLMS) which can be very disruptive to both the patient
and to her/his sleeping partner.
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Depression And
Anxiety- do co-exist with fibromyalgia, therefore their treatment is
important as both can exacerbate FM and interfere with successful symptom
management.
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Sensory
Sensitivity/Allergic Symptoms: Hypersensitivity to light,
sound, touch, and odors frequently occurs among those with FM and is thought to
be a result of a hyperactive nervous system. In
addition, persons with FM may feel chilled or cold when others around them are
comfortable, or they may feel excessively warm. They may also have allergic-like
reactions to a variety of substances accompanied by itching or a rash or a form
of non-allergic rhinitis consisting of nasal congestion/discharge and sinus
pain. However, when such symptoms occur, there is usually no measurable immune
system response like that found in true allergies.
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Skin Complaints:
Nagging symptoms, such as itchy, dry, or blotchy skin, may accompany FM. Dryness
of the eyes and mouth is also not uncommon. Additionally, fibromyalgia patients
may experience a sensation of swelling, particularly in extremities (i.e.,
fingers). However, such swelling is not like the joint inflammation of
arthritis; rather, it is a localized anomaly of FM of unknown cause.
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Dysequilibrium:
FM patients may be troubled by light-headedness and/or balance problems for a
variety of reasons. Since fibromyalgia is thought to affect the skeletal
tracking muscles of the eyes, "visual confusion" and nausea may be
experienced when driving a car, reading a book, or otherwise tracking objects.
Weak muscles and/or trigger points in the neck or TMJ dysfunction may cause
dizziness or dysequilibrium. Researchers at
Johns
Hopkins
Medical
Center
have also shown that some FM patients have a condition known as "neurally
mediated hypotension" which causes a drop in blood pressure and heart rate
upon standing with resulting light-headedness, nausea, and difficulty thinking
clearly.
Fibromyalgia
symptoms are better understood today than a few years ago. Also, the
interrelatedness of various factors are understood,
and can be used to aid in treatment.
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Difficult
to diagnose, Fibromyalgia was once mistaken for fibrositis and is often confused
with chronic fatigue syndrome. People with Fibromyalgia often do not look sick
or show abnormalities in laboratory tests but say they have almost constant and
sometimes terrible pain.
As there
is currently no reliable laboratory test available to make the diagnosis of FMS,
the examining physician have to rely on a patient's
medical history and physical
findings of tender points on examination. Palpation
of muscles and muscle-tendon junctions will show many tender points.
In 1990,
The American College of Rheumatology established criteria to make the diagnosis
of FMS that include the presence of 11 tender
points at 18 specified sites. A diagnosis is usually helpful because
now you know there is a name for your symptoms. Usual laboratory tests come out
negative.
Previously
we did not know if anything was abnormal, but now it is clear that many neuroendocrine
tests are abnormal (for example, serotonin is low, substance P is
high, etc). A recently reported blood test (still in experimental stage)
detected an antibody (called APA) in about 50% of Fibromyalgia patients studied.
In the past 10-15 years significant progress has been made. A satisfactory test
for FMS may be available in the future.
Successful
treatment of your Fibromyalgia symptoms involves treating yourself with kindness
and respect, both emotional and physical. Adopting and adhering to positive
lifestyle habits will not only help ease the painful effects of Fibromyalgia,
but also promote overall health. These are habits that could benefit anyone of
any age and in any state of wellness. Best of all, these habits, when used as
part of your everyday routine, will help prevent or reduce pain, disease and
depression.
It is
difficult to treat Fibromyalgia since the symptoms can vary so widely and the
cause is unknown. Your doctor will work with you to develop a specific treatment
plan, tailored to your condition and the severity of your symptoms of
fibromyalgia. This may include a combination of :
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Analgesics
-such as paracetamol, and even more powerful pain medications to relieve
pain and help with sleep.
It
is important to avoid prescription tranquilizers and sleeping
medications especially of the benzodiazepine group. While
these may help you get to sleep, they suppress deep sleep and
therefore often make fibromyalgia worse!
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Low
doses of antidepresssants and muscle relaxants
to help with sleep and mood.
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Laser
therapy- to improve pain intensity to a greater degree in
combination with amitriptyline which has a
greater effect on depression as reported by
investigators from the Dicle University
School of Medicine in Diyarbakir and Abant Izzet Baysal
University in D�zce, Turkey. The investigators
compared three groups of 25 patients each that were treated with active
gallium-arsenide laser, amitriptyline or placebo
laser treatment. Laser treatment was performed for three minutes daily at
each tender point for two weeks, excluding weekends. Placebo laser treatment
used the same laser unit, but no beam was emitted. Amitriptyline
treatment consisted of 10 milligrams daily at bedtime for eight weeks.
Improvements in pain, number of tender points, skin fold tenderness, morning
stiffness, sleep disturbance, muscular spasm and fatigue were assessed.
Also, a psychiatrist evaluated depression based on the Hamilton Depression
Rate Scale and DSM IV criteria. Quality of life was assessed by the
Fibromyalgia Impact Questionnaire. The investigators conclude that both
laser therapy and amitriptyline are effective
for Fibromyalgia. Gallium-arsenide laser therapy could be used as a monotherapy
or in combination with other therapies, they suggest.
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Note:
The above mentioned medication is only for information purpose and not to be
substituted for a Doctor's prescription.
Exercise
helps, although it might be the last thing you feel like doing if you're in a
lot of pain. It can be helpful in reducing
muscle soreness. While no studies have found that exercise improves
pain, it has been shown to help patients function better, improve mood, and
reduce fatigue. (Reported
by:Annals of Rheumatic
Disease 2001; 60: 21-26).
In
addition to improving strength and circulation, exercise can help increase
your range
of motion. It is important to stretch
thoroughly, both before and after exercise to keep your muscles
loose. Gentle stretching can be performed by physical therapists and/or
practiced by patients at home. Stretching is important because it helps to
relieve muscle tension and spasm. Patients can also perform
stretching exercises
using a "Theraband", a long elasticized
strip which is manipulated in a number of ways, or an oversized, inflatable
"Swiss ball" over which they can extend themselves in different ways
to stretch and strengthen tight muscles.
Generally,
low-impact exercise,
such as water aerobics or walking are recommended for patients with fibromyalgia
to prevent muscle atrophy (wasting), to promote the circulation of blood
containing oxygen and other nutrients to muscles and connective tissue, and to
build strength and endurance. A cardinal rule for fibromyalgia patients is to start
extremely slowly and conservatively and build
up exercise tolerance in increments. In fact, patients should find a
form of exercise they like so that they will stick to it on a regular basis.
NOTE: Do not forget to take the permission of your doctor before starting on an
exercise program.
Patients
with Fibromyalgia can boost their strength and improve certain parameters with weight-bearing
exercise, researchers from Finland have demonstrated, women with
fibromyalgia completed a 21-week strength training program and it was found to
reduce their levels of depression
and fatigue,
but pain levels did not change.
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Researchers
divided 21 women with fibromyalgia into two groups.
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Eleven
women went through the strength training program and 10 received no special
care.
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An
additional 12 healthy women went through the weight training program as
"control" subjects.
Physical
therapy modalities also can be helpful in alleviating your symptoms. Physical
therapists may use massage, heat
or cold, ultrasound, electrical
stimulation, or any combination of exercise,
to help reduce your muscle soreness. Massage often combined with ultrasound
and/or the application of hot/cold packs, may be performed in a number of ways
and is useful in soothing and increasing blood circulation to tense, sore
muscles. It can also help remove built-up toxins like lactic acid and re-educate
muscles and joints which have become mechanically misaligned.
In
addition, physical or occupational therapists may work on your posture
or gait to help improve your ongoing symptoms. Posture or movement training is
often required to undo lifelong bad habits which increase pain and to re-educate
muscles/joints that have become mechanically misaligned. Physical therapists can
help with posture while professionals trained in the "Alexander
Technique" can provide movement training. FM patients who have significant
problems with foot pain resulting from poor posture or body mechanics may also
benefit from special shoe inserts (orthotics)
prescribed by a podiatrist.
Meditation,
deep breathing, practicing
yoga,
visualization and other mind
body practices, such as
tai chi and qigong, have been found to ease
some symptoms- sometimes dramatically. Patients however, need to receive initial
training for many of these but can often continue practicing the concepts they
have learned on their own. Books, audiotapes, and classes are widely available
to help.
Modifications
brought about in dietary pattern might prove helpful in counteracting stress,
ridding the body of toxins, and restoring nutrients which have been mal-absorbed
or robbed from the body.
Adding magnesium
to diet by consuming food sources like, legumes, grains, seeds, resin, tofu,
kelp, dark green vegetables, and nuts. Low magnesium levels might lead to muscle
spasm, which then causes muscle pain. Combining magnesium with the Krebs cycle
intermediate malic acid can decrease pain in as
little as 48 hours. Typical total daily doses of magnesium required are 500-1000
mg, while 1200 to 2400 mg of malic acid is needed.
Other
nutrients which have been found to be of value in treatment include niacinamide,
a form of
Vitamin B3 which helps
reduce muscle inflammation. Doses of 1000 up to 4000 mg daily are required,
which, because of the size of the dosage, necessitates monitoring of liver
function.
Vitamin C in large
doses, such as several grams daily, in combination with 400 to 1200 IU of
Vitamin
E daily can assist in cartilage repair, as well as control of
inflammation. Eicosapentanoic acid (EPA), the
omega-3
essential fatty acid found in fish, also contributes to the
anti-inflammatory effect, and should be taken in doses of 1800 mg a day. The
minerals
selenium and
zinc
are also of benefit. Selenium levels are typically quite low in fibromyalgia,
and selenium works in conjunction with Vitamin E to control inflammation. 200
mcg a day should be taken, while zinc in doses of 25-50 mg a day helps promote
tissue repair.
Some
studies suggest that over 50% of fibromyalgia patients also have carbohydrate
intolerance with associated
hypoglycemia. A diet which emphasizes elimination
of simple sugars and encourages moderate
protein intake at the expense of carbohydrates may help many
patients. There are a few other dietary modifications which may be of value.
Apples are a rich source of malic acid, which as
noted above is beneficial in this disease. Increasing
intake of apples and apple containing products is a valuable adjunct.
Nutritionists
commonly urge fibromyalgia patients to limit
the amount of sugar, caffeine, and alcohol they consume since these substances
have been shown to irritate muscles and stress the system. In addition, avoidance
of foods in the nightshade family such as tomatoes, potatoes, eggplant, and
peppers may be helpful to some patients.
About 90%
of people with fibromyalgia are women. It is all too easy for women with FM to
be excessively hard on themselves. It takes enormous
energy as well as courage to adjust to FM and find treatments that work well
without wasting precious energy on guilt, self- deprecation, and doubt.
Attitude
is often one of the strongest predictors of how well a patient will be able to
manage Fibromyalgia. Patients who are not actively engaged in taking charge of
their illness simply aren't as likely to get better. Patients
need to take up effective
stress
management
program
in consultation with their.
Try to
follow a regular sleep pattern:
Patients with FMS must get to bed by the same time every night and sleep as long
as they need to. Staying up just one hour late may precipitate an exacerbation
that lasts for several days. Many patients with fibromyalgia have exacerbations
triggered by the change over to or from Daylight Savings time.
For best
results, you need to be actively involved in your treatment and to have as clear
an understanding of this complicated disorder as possible.
Rheumatologist
and FM specialist Russell Rothenberg, M.D., has words of hope to share. Just
because someone starts out with severe symptoms doesn't mean that (s)he
cannot find worthwhile improvement with a skillfully devised and comprehensive
treatment program. "Patients need to know that medication, judicious rest,
exercise, physical therapy, and good diets can do more than just control the
symptoms of fibromyalgia; they can control the disease process as well. There is
no cure for FM, but people do get better! Hopefully, as better medications that
are more specific for fibromyalgia are developed, and people are diagnosed
earlier in their illness, more individuals with fibromyalgia will go into
remission, or at least partial remission, and feel better."
References:
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1. Stuart
Donaldson, Ph.D., et al., "Fibromyalgia: A Retrospective Study of 252
Consecutive Referrals," Canadian
Journal of Clinical Medicine, Vol. 5, # 6, June 1998.
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Rheumatol Int 2002;
22: 188-193. "Effects of low power laser and low dose
amitriptyline therapy on clinical symptoms and quality of life in fibromyalgia: a single-blind, placebo-controlled trial".
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