This is a long-awaited book which has been written by an internationally-renown author with extensive experience on this subject. The book is very informative with well chosen references which can help the readers to go deeply into their subjects of interest. I myself have used it and recommend it as a reference book and aslo a teaching book. It is detailed enough for those already familiar with CVD epidemiology and also well written enough for those who are just starting to study this issue. Congratulation to Dr. Labarthe for his great masterpiece.