Each year, foot ulcers lead to more than 82,000 amputations. They’re a devastating complication of diabetes. Type II, or adult onset, diabetes accounts for most cases of the disease. People who are overweight, have a family history of diabetes, are over age 45, were gestational diabetics (women who had high blood sugar levels during pregnancy), or are African American, Latin American, Native American, or Asian and Pacific Islanders, have a higher risk of developing diabetes than others. Symptoms of Type II diabetes include extreme thirst, excessive urination, unexplained weight loss, blurred vision, and tingling or numbness in the hands or feet.
The sole, or plantar surface, of the foot is the most common location for an ulcer. Problems can begin with something as seemingly innocuous as a bunion or a hammertoe and a poorly fitting shoe that rubs against these deformities. “Every time you have an ulcer, this is just one more opportunity to develop a limb-threatening infection that might require an amputation,” says Jeffrey Johnson, M.D., an orthopedic foot and ankle surgeon from Barnes-Jewish Hospital at Washington University School of Medicine in St. Louis.
Researchers at Washington University say healing the ulcers is tough, but keeping them healed is tougher. Dr. Johnson says: “The problem is the recurrence rate is very high. Within the first month after healing these ulcers … 60 percent or 80 percent of patients will re-ulcerate during that time.”
Now, researchers are turning to Botulinum Toxin Type A, or Botox — a poison that’s commonly used to treat wrinkles.
Wounds are most common on the ball of the foot, and the pressure on wounds is highest when a person walks. That’s where Botox comes in. “What the botulism will do is weaken that muscle, the muscle that pushes you forward during walking, and so then you can’t develop the high pressures under the front of your foot,” says Mary Hastings, a physical therapist at Washington University who is leading the study. Botox allows time for the ulcer to heal.
In a new study, doctors will inject Botox in six different places in the calf muscle. Then, they’ll cast it. They know the Botox will weaken the muscle, and they hope that’s enough to keep the wounds healed.
“The more time you spend without a sore on the bottom of the foot, the less chance you have for an infection that will develop into the potential for a need for an amputation,” Hastings says.
The study has already started enrolling patients. And for the more than 18 million diabetics in the Unites States, that’s encouraging news.
Botox is already approved by the FDA to treat other medical conditions. Daily inspections of your feet are the best way to prevent infections, but if they do occur, you need a healthcare team with special expertise in diabetic foot problems.
Shoe selection and modifications:
- Obtain well-cushioned walking shoes
- Shoes should have adequate room in toe box
- Consider custom molded shoes
- Break in a new shoe gradually
- Reduce pressure points
- Cushioned insole
- Custom Orthotic
The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.