BMI: A Factor In Cervical Cancer Risk

Obesity continues to be linked to a multitude of health problems, from increased blood pressure and heart disease to sleep apnea, breathing problems and gallstones. In women, excessive fat has been shown to increase levels of estrogen. Estrogen and its receptors are implicated in the promotion and prevention of various cancers. Virtually all cervical cancers derive from human papillomavirus (HPV) infection. Cervical cancer develops slowly, is often established over a decade after initial infection with high-risk HPVs, and only arises in those women whose infections do not resolve spontaneously.

Height and weight which constitute the Body Mass Index (BMI) can be a contributing factor for cervical cancer.

In a study which evaluated a variety of potential risk factors in 560 women: 124 diagnosed with adenocarcinoma (a type of cervical cancer linked specifically to high estrogen levels); 139 with squamous-cell cervical cancer; and 307 women who did not have cancer.

Among their findings:

Women who were heavier, had a high body mass index (BMI) or had fat that was concentrated in the midsection were far more likely to have adenocarcinoma.
Women with a BMI greater than 30 (considered clinically obese) and “apple-shaped” women (those with high waist-to-hip ratios) were both twice as likely to develop adenocarcinoma.
Women with high BMIs had more advanced stages of adenocarcinoma when they were diagnosed with cancer, even if they received regular Pap smear.

According to the results of a retrospective cohort study, overweight and underweight women with cervical cancer did not live as long as their normal-weight counterparts. The median overall survival time in overweight/obese women was 6 months shorter than in women of normal weight (22 versus 28 months). For underweight women, median overall survival time was cut in half (14 versus 28 months), reported Leslie Clark, MD, of the University of North Carolina at Chapel Hill, and colleagues.

Adenocarcinoma.

It is a type of cancer that starts in the glands that line the inside of one of the organs. Adenocarcinoma can happen in many places, like your colon, breasts, esophagus, lungs, pancreas, or prostate. It is caused when cells in the glands that line your organs grow out of control. They may spread to other places and harm healthy tissue.

Symptoms may vary from pain, diarrhea, bleeding, or fatigue, depending on your type of cancer. But early on, you may not feel that anything’s wrong.
A physical exam can help check the organ to see if there is any swelling or a growth.

Women who are obese should speak with their physician about ways to lose weight and the benefits of a healthy, low-fat diet, and receive more frequent Pap smears to detect the early signs of adenocarcinoma.

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Disclaimer
The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.