(Ivanhoe Newswire) -- A new study suggests older women with breast cancer,
who are otherwise in good health, may be dismissed as candidates for treatment
with chemotherapy.
Previous data shows secondary treatment chemotherapy in women with early
stage breast cancer significantly improves survival for women in their 50s and
60s, but there is little data among women ages 70 and older. Researchers suggest
chemotherapy may be significantly underused or dosages may be too low for this
population.
Researchers from the Vermont Cancer Center in Burlington and the Cancer and
Leukemia Group B analyzed data from clinical trials of treatments for breast
cancer patients from over a 14-year period. The trials compared more aggressive
and less aggressive chemotherapy regimens.
Researchers found no association between age and disease-free survival. Both
older and younger women had similar reductions in breast cancer mortality and
recurrence from regimens with aggressive chemotherapy. However, only 8 percent
of patients studied were ages 65 or older, and about half of new breast cancer
cases occur in this age group.
Researchers conclude, "Our study adds to the increasing number of trials that
suggest that older patients in fair to good health tolerate standard
chemotherapy regimens, and even more intensive regimens, almost as well as
younger patients. The data from this study should help to encourage clinicians
to offer healthy older patients participation in newer trials."
SOURCE: The Journal of the American Medical Association,
2005;293:1118-1119