(Ivanhoe Newswire) -- Researchers know the Mediterranean diet seems to
protect against breast cancer, and they now know the reason why. After running a
series of laboratory experiments, researchers from the Northwestern University
Feinberg School of Medicine in Evanston, Ill., discovered why a high intake of
oleic acid-rich olive oil fights cancer.
Researchers found oleic acid dramatically cuts the levels of a gene called
Her-2/neu. High levels of Her-2/neu are associated with aggressive tumors in
many breast cancer patients. Additionally, researchers found oleic acid boosts
the effectiveness of the antibody treatment trastuzumab (Herceptin), which
targets Her-2/neu and helps prolong the life of breast cancer patients. Oleic
acid was also found to increase the expression of a tumor suppresser
protein.
Researchers emphasize it is important to be cautious about the implications
of the study, as laboratory results do not always translate into clinical
practice. However, they say the findings do suggest a higher level of oleic acid
in breast tissue could provide an effective means of influencing the outcome of
breast cancer patients who have high levels of Her-2/neu.
Researchers say, "Our findings underpin epidemiological studies that show the
Mediterranean diet has significant protective effects against cancer, heart
disease, and aging."
The Mediterranean diet includes consumption of whole grains, fruits,
vegetables, nuts, and olive oil.
SOURCE: Annals of Oncology, published online Jan. 10, 2005