(Ivanhoe Newswire) -- A new scientific discovery could one day lead to the
prevention of type 1 diabetes and other autoimmune diseases. Researchers from
the University of Maryland School of Medicine in Baltimore have found a way to
prevent type 1 diabetes in rats that are generally prone to develop the
disease.
In earlier research, scientists discovered the human protein zonulin and
found it is produced in very large amounts in people with autoimmune diseases.
This overproduction triggers a number of other reactions that lead to the
production of antibodies that can destroy insulin-producing cells in people
genetically predisposed to develop type 1 diabetes.
In the new study, researchers used diabetes-prone rats to test the
effectiveness of a zonulin inhibitor peptide called AT-1001. The peptide
prevented diabetes from developing in the vast majority of animals tested.
Researchers say, "In essence, we saw that this peptide stopped the sequence of
events that leads to diabetes."
Researchers add this discovery could eventually lead to the development of an
oral medication to arrest autoimmune diseases in the early stages. Clinical
trials will soon begin to test the use of AT-1001 in patients with celiac
disease -- a digestive disease that damages the small intestine and interferes
with absorption of nutrients from food.
SOURCE: Proceedings of the National Academy of Sciences,
2005;102:2916-2921