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Nicotine Patch Plus Lozenge is Best
Reported November 06, 2009
(Ivanhoe Newswire) -- If you really want to quit smoking this time,
try combining a nicotine patch plus a nicotine lozenge for best results.
Megan E. Piper, Ph.D., of the University of Wisconsin Center for Tobacco
Research and Intervention, Madison, and colleagues conducted a randomized
clinical trial of smoking cessation therapies involving 1,504 adults. All
participants had smoked at least 10 cigarettes a day during the previous six
months and were motivated to quit. Participants were randomly assigned to
one of six treatment groups: nicotine lozenge alone, nicotine patch alone,
bupropion alone, patch plus nicotine lozenge, bupropion plus nicotine
lozenge, or placebo. All participants received six individual counseling
sessions.
When all the treatments were compared at the six-month point, only the
individuals in the patch plus nicotine lozenge group were more successful in
quitting than those taking placebo. Smokers using a patch and nicotine
lozenge were also more likely to have quit at seven days and tended to have
other more positive outcomes, such as a longer period of time before
relapsing. This combination, along with the patch alone, most effectively
helped people achieve at least one day of abstinence from smoking, an
important step to successful quitting.
"The present results suggest that the nicotine lozenge can also be effective
as an adjuvant [additional treatment] to the nicotine patch," the authors
were quoted as saying. "The key seems to be that an ad libitum, or ‘as
needed,’ agent must be paired with the patch. Simply using higher patch
doses does not seem to augment outcomes to the same degree."
The lozenge, though effective with the patch, did not appear to work any
better than placebo when used alone.
"These findings . . . suggest that a combination pharmacotherapy comprising
the nicotine patch and an ad libitum nicotine replacement therapy should be
routinely considered for use as a smoking cessation treatment," the authors
wrote. "In addition, this study illustrates that after more than 20 years
the patch remains a highly efficacious pharmacotherapy for helping people
quit smoking."
SOURCE: Archives of General Psychiatry, November, 2009 |