Long Term Impact of Osteoporosis
Reported March 12, 2010
(Ivanhoe Newswire) — Bisphosphonate treatments, proven to enhance bone density and reduce fracture incidence in post-menopausal women, may adversely affect bone quality and increase risk of atypical fractures of the femur when used for four or more years. Bisphosphonates are designed to slow or stop the bone loss that occurs during the body’s bone remodeling cycle, the natural process that involves removal and replacement of bone tissue.
Researchers from Hospital for Special Surgery (HSS) and Columbia University Medical Center revealed data suggesting that long-term suppression of bone remodeling by bisphosphonate treatments may alter the material properties of bone, potentially affecting the bone’s mechanical integrity and possibly contributing to the risk of atypical fractures.
“Although bisphosphonates have demonstrated an improvement in bone quantity, little if anything is known about the effects of these drugs on bone quality,” Brian Gladnick, BS, representing a team of investigators at HSS in New York, was quoted as saying.
Researchers at Columbia evaluated the bone structure of 111 postmenopausal women with primary osteoporosis. Sixty-one of them had been taking bisphosphonates for a minimum of four years, and 50 controls had been taking calcium and vitamin D supplements.
The study found that bisphosphonate use improved structural integrity early in the course of treatment, but those gains diminished with long-term treatment.
“In the early treatment period, patients using bisphosphonates experienced improvements in all parameters, including decreased buckling ratio and increased cross-sectional area,” Melvin Rosenwasser, MD, orthopedic surgeon for Columbia University Medical Center, was quoted as saying. “However, after four years of use, these trends reversed, revealing an association between prolonged therapy and declining cortical bone structural integrity.”
Scientists noted that the culprit behind the diminishing results may be the fact that bisphosphonates suppress the body’s natural process of remodeling bone. “Recent research suggests that suppressed bone remodeling from long-term bisphosphonate use might result in brittle bone that is prone to atypical fractures,” said Gladnick.
The investigators added that more research is needed to determine the true efficacy of the long-term clinical use of bisphosphonates for the treatment of osteoporosis, and that the results of their studies will not likely affect clinical practice in the near future.
“Bisphosphonate use still is a very effective solution that prevents bone loss in most patients and no one is recommending that physicians avoid prescribing these,” said Dr. Rosenwasser. “However, as baby boomers age and continue to remain active, it is important that we conduct more research and develop sustainable, safe and effective treatments for osteoporosis.”
In a second unrelated study conducted at HSS, researchers evaluated the bone composition of 21 post-menopausal women who were treated for femoral fractures. Of these, 12 patients had a history of bisphosphonate treatment for an average of 8.5 years, while nine had not had bisphosphonate treatment.
“Patients who had been treated with bisphosphonates showed a reduction in tissue heterogeneity, specifically with mineral content and crystal size compared with the control group,” Gladnick said. “This tells us that there may be some measurable differences in bone quality parameters in patients on long-term bisphosphonate therapy, which might contribute to the development of atypical fractures.”
SOURCE: Presented at the Annual Meeting of the American Academy of Orthopedic Surgeons (AAOS), March 10, 2010
