For women who’ve had breast cancer and would like to have a child, taking a break from a common treatment to try for a pregnancy appears safe in the short term. A clinical trial studied the effect of temporarily halting hormone therapy, also called endocrine therapy, which reduces the risk that breast cancer will return. After about three years, the incidence of recurring or … [Read more...]
Fasting Diet Reduces Risk Markers of Type 2 Diabetes
Researchers from the University of Adelaide and South Australian Health and Medical Research Institute (SAHMRI) compared two different diets: a time restricted, intermittent fasting diet and a reduced calorie diet to see which one was more beneficial for people who were prone to developing type 2 diabetes. "Following a time restricted, intermittent fasting diet could help … [Read more...]
Exposure Therapy to Feared Foods may Help kids with Eating Disorders
According to the National Eating Disorders Association, approximately 30 million Americans will struggle with eating disorders, including anorexia nervosa, bulimia nervosa, binge-eating disorder and others, at some point in their lives. In addition to the LGBTQ+ community, adolescents and young adults are particularly vulnerable, and the COVID-19 pandemic didn't help. Recent … [Read more...]
People with Obesity due to Genetic Predisposition have Lower Risk of Cardiovascular Disease
There has been a global increase in the incidence of overweight and obesity over the past few years. Almost one third of the world's population now liveswith overweight or obesity. "The figure is alarming since it is well-established that a high BMI in middle-age increases the risk of developing cardiovascular disease and other conditions," says Ida Karlsson, assistant … [Read more...]
Oral Barrier is Similar in Ceramide Composition to Skin Barrier
The skin is the body's first line of defense against the environment, particularly against pathogens, chemicals, and allergens. It is now known that a class of biological molecules called acylceramides and their metabolites, protein-bound ceramides, are essential to the formation of this barrier. The outermost tissues of the mouth are closely related to the skin and have … [Read more...]
Obesity Turning Arthritic Joint Cells into Pro-inflammation “Bad Apples”
In a new study published in Clinical and Translational Medicine today, researchers from the University of Birmingham have found that specific cells in the joint lining tissue (synovium) of patients with osteoarthritis are being changed due to factors associated with obesity. Previous research has shown that fat tissue that has been metabolically altered by obesity releases … [Read more...]
How to Prevent a High-Fat Diet From Throwing Metabolism Out of Whack?
The UC Irvine research centered on a protein complex called AMPK, which senses the body's nutrition and takes action to keep it balanced. For example, if AMPK detects that glucose is low, it can boost lipid breakdown to produce energy in its place. Scientists have known that consuming high amounts of fat blocks AMPK's activity, leading the metabolism to go out of balance. … [Read more...]
New Test Could Help Identify Type 2 Diabetes Risk
Scientists looked at the influence of these changes -- known as DNA methylation -- alongside other risk factors in almost 15,000 people to predict the likelihood of developing the condition years in advance of any symptoms developing. The findings could lead to preventative measures being put in place earlier, reducing the economic and health burden caused by type 2 … [Read more...]
Non-Biological Factors and Social Determinants of Health Important in Women’s CVD Risk Assessment
"Risk assessment is the first step in preventing heart disease, yet there are many limitations to traditional risk factors and their ability to comprehensively estimate a woman's risk for cardiovascular disease," said Jennifer H. Mieres, M.D., FAHA, vice chair of the scientific statement writing committee and a professor of cardiology at the Zucker School of Medicine at Hofstra … [Read more...]
Beetroot juice: Significantly Increases Muscle Force During Exercise
While it is known that dietary nitrate enhances exercise, both boosting endurance and enhancing high-intensity exercise, researchers still have much to learn about why this effect occurs, and how our bodies convert dietary nitrate that we ingest into the nitric oxide that can be used by our cells. To help close this gap, researchers at the University of Exeter and the U.S. … [Read more...]
Physical Activity can Help Mental Health in Pre-teen Years
Engaging in regular moderate to vigorous physical activity at age 11 was associated with better mental health between the ages of 11 and 13, the study found. Physical activity was also associated with reduced hyperactivity and behavioural problems, such as loss of temper, fighting with other children, lying, and stealing, in young people. Researchers from the Universities … [Read more...]
Assessing the Risk of Excess Folic Acid Intake
"However, there is a lack of research on whether excessive folic acid intake has the potential to harm human beings," said co-corresponding author, Dr. Richard H. Finnell, William T. Butler, M.D., Distinguished Chair Professor in the Center for Precision Environmental Health and the departments of molecular and cellular biology, molecular and human genetics and medicine at … [Read more...]
Study Reveals New Understanding of How Androgen Therapy Affects Breast Tissue
Transgender men who were assigned female at birth and identify today as male may take hormones called androgens to induce physical changes that help them align their physical appearance with their identified gender. Androgens such as testosterone are involved primarily in the development of male traits, although females also produce androgens. Molecular changes observed in … [Read more...]
Adding Antipsychotic Med to Antidepressant May help Older Adults with Treatment-Resistant Depression
Aripiprazole originally was approved by the FDA in 2002 as a treatment for schizophrenia but also has been used in lower doses as an add-on treatment for clinical depression in younger patients who do not respond to antidepressants alone. The new findings are published March 3 in The New England Journal of Medicine and are to be presented that same day by Eric J. Lenze, MD … [Read more...]
Mocktails or Cocktails? Having a Sense of Purpose in Life can Keep Binge Drinking at Bay
Using functional MRI (fMRI) scanning technology, researchers from the University of Pennsylvania, Columbia University, and Dartmouth College examined the relationship between these cues, alcohol craving, and alcohol consumption. They found that having a strong sense of purpose in life decreases the temptation to consume alcohol to excess among some social drinkers. Why … [Read more...]
Will Revitalizing Old Blood Slow Aging?
Many scientists are looking for the elements of young blood that can be captured or replicated and put into a pill. But what if the best way to get the benefits of young blood is to simply rejuvenate the system that makes blood? "An aging blood system, because it's a vector for a lot of proteins, cytokines, and cells, has a lot of bad consequences for the organism," says … [Read more...]
Youth Overweight a Risk Factor for Blood Clots as Adult
The association between obesity and blood clots is already established. However, to date it has been unclear how much influence a raised BMI in childhood and puberty exerts. The purpose of the study was to clarify the links between BMI in early life and subsequent thrombi. Thrombi usually arise in the legs, often starting in a blood vessel in the calf. Swelling, pain and … [Read more...]
Rhythmic Eating Pattern Preserves Fruit Fly Muscle Function Under Obese Conditions
Obese fruit flies are the experimental subjects in a Nature Communications study of the causes of muscle function decline due to obesity. In humans, skeletal muscle plays a crucial role in metabolism, and muscle dysfunction due to human obesity can lead to insulin resistance and reduced energy levels. Interestingly, studies in various animal models have shown that … [Read more...]
Effect of Dietary Choline Deficiency on Neurologic and System-Wide Health
It's estimated that more than 90% of Americans are not meeting the recommended daily intake of choline. The current research, conducted in mice, suggests that dietary choline deficiency can have profound negative effects on the heart, liver and other organs. Lack of adequate choline is also linked with profound changes in the brain associated with Alzheimer's disease. These … [Read more...]
Body Dissatisfaction Can Lead to Eating Disorders at Any Age
Body Dissatisfaction Can Lead to Eating Disorders at Any Age ++nutrition Eating disorders are serious mental health conditions characterized by disturbances in eating behavior and body image that occur in approximately 13.1% of women across the lifespan. The prevalence of any eating disorder specifically for women aged older than 40 years is roughly 3.5%, with specific … [Read more...]
Preterm Birth Linked to Chemicals Found in the Vagina, Study Finds
The study of 232 pregnant women found that a handful of non-biological chemicals previously found in cosmetics and hygiene products are strongly associated with preterm birth. "Our findings suggest that we need to look more closely at whether common environmental exposures are in fact causing preterm births and, if so, where these exposures are coming from," says study … [Read more...]
Feeling Depressed? Performing acts of Kindness may help
People suffering from symptoms of depression or anxiety may help heal themselves by doing good deeds for others, new research shows. The study found that performing acts of kindness led to improvements not seen in two other therapeutic techniques used to treat depression or anxiety. Most importantly, the acts of kindness technique was the only intervention tested that … [Read more...]
Consumption of Fast Food Linked to Liver Disease
A study from Keck Medicine of USC published today in Clinical Gastroenterology and Hepatology gives people extra motivation to reduce fast-food consumption. The study found that eating fast food is associated with nonalcoholic fatty liver disease, a potentially life-threatening condition in which fat builds up in the liver. Researchers discovered that people with obesity … [Read more...]
Better Planning, Behavior Regulation can Lead to Eating Less Fat
New research suggests coaching overweight or obese pregnant women to improve their ability to plan and make progress toward goals may be key to helping them lower the amount of fat in their diet. Maternal diet quality affects prenatal development and long-term child health outcomes, but the stress that typically increases during pregnancy -- often heightened by concern for … [Read more...]
Discovery of Metabolic Switch Could Lead to Targeted Treatment of Obesity, Cancer
An Iowa State University research team has discovered a method for modifying the function of an enzyme crucial to fat production, which could lead to more effective treatments for childhood obesity and cancer. While the research was in fruit fly larvae, being able to speed up or slow down lipid metabolism could have significant implications for human health, said Hua Bai, … [Read more...]
Does The Risk of Stroke From Common Risk Factors Change as People age?
"High blood pressure and diabetes are two important risk factors for stroke that can be managed by medication, decreasing a person's risk," said study author George Howard, DrPH, of the University of Alabama at Birmingham School of Public Health. "Our findings show that their association with stroke risk may be substantially less at older ages, yet other risk factors do not … [Read more...]
Study Reveals Obesity-Related Trigger That can Lead to Diabetes
A new study at Washington University School of Medicine in St. Louis may help explain how excess weight can contribute to diabetes and may provide researchers with a target to help prevent or delay diabetes in some of those at risk. The findings suggest that many people with elevated levels of insulin -- an early marker of diabetes risk -- also have defects in an enzyme … [Read more...]
Honey reduces cardiometabolic risks, study shows
The researchers conducted a systematic review and meta-analysis of clinical trials on honey, and found that it lowered fasting blood glucose, total and LDL or 'bad' cholesterol, triglycerides, and a marker of fatty liver disease; it also increased HDL or 'good' cholesterol, and some markers of inflammation. "These results are surprising, because honey is about 80 per cent … [Read more...]
Brain Organoids Reveal in Detail the Harms of Prenatal Alcohol Exposure
The consequences of prenatal alcohol exposure (PAE) are reflected in the different diagnoses that emerge under the umbrella of fetal alcohol spectrum disorders. At one end of the spectrum, growth deficits and physical differences define fetal alcohol syndrome (FAS), but in most cases, irreversible brain damage leads to behavior and learning challenges even without a physical … [Read more...]
Study Compares Adverse Events After Two Types of Bariatric Surgery in Adolescents
Adolescents who underwent sleeve gastrectomy, a type of weight-loss surgery that involves removing part of the stomach, were less likely to go the emergency room or be admitted to the hospital in the five years after their operations than those who had their stomachs divided into pouches through gastric bypass surgery, according to new research. Rates of complications, death … [Read more...]
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