Cancer cells need nutrients to survive and grow. One of the most important nutrient sensing molecules in a cell is called mTORC1. Often called a master regulator of cell growth, it allows cells to sense different nutrients and thereby grow and proliferate. When nutrients are limited, cells dial down nutrient sensing cascade and turn off mTORC1. While mTORC1 is known to be … [Read more...]
Exercise can Reduce Severity of Breast Cancer Rreatment Side Effects
Breast cancer is the most common form of the disease among women; in Australia, one in eight women will be diagnosed with breast cancer by the age of 85. Radiotherapy has emerged as an important component of breast cancer treatment but can lead to cancer-related fatigue and negatively impact patients' health-related quality of life including their emotional, physical and … [Read more...]
Black tea (and other favorites) may help your health later in life
A daily cup of tea could help you to enjoy better health late in life -- however if you're not a tea drinker, there are other things you can add to your diet. The key is flavonoids, which are naturally occurring substances found in many common foods and beverages such as black and green tea, apples, nuts, citrus fruit, berries and more. They have long been known to have … [Read more...]
Healthy Aging Requires an Understanding of Personality Yypes
New research shows that older adults may be better supported as they age when their personalities are considered -- for example, are they more like orchids or dandelions? Researchers from Simon Fraser University's Circle Innovation examined the potential effects of lifestyle activities on the cognitive health of more than 3,500 adults aged 60+, and found that … [Read more...]
Which Grains you Eat can Impact Your Risk of Getting Heart Disease Earlier
In one of the first studies to examine the relationship between different types of grain intake and premature coronary artery disease in the Middle East, researchers found a higher intake of refined grain was associated with an increased risk of premature coronary artery disease in an Iranian population, while eating whole grains was associated with reduced risk. The study will … [Read more...]
Combining Time-Restricted Eating and HIIT Improves Health Measures in Women with Obesity
Both time-restricted eating (TRE) and high-intensity interval training (HIIT) have been shown to improve cardiometabolic health in people who are overweight and at risk of serious disease. Now a randomized, controlled trial has tested whether combining these two approaches is more effective than either of them on their own. The results, publishing in the journal Cell Metabolism … [Read more...]
Scientists Chart How Exercise Affects The Body
Exercise is well-known to help people lose weight and avoid gaining it. However, identifying the cellular mechanisms that underlie this process has proven difficult because so many cells and tissues are involved. In a new study in mice that expands researchers' understanding of how exercise and diet affect the body, MIT and Harvard Medical School researchers have mapped out … [Read more...]
Prenatal Acetaminophen use Linked to Sleep, Attention Problems in Preschoolers
Acetaminophen use during pregnancy is associated with sleep and behavior problems consistent with attention deficit hyperactivity disorder (ADHD), according to a study by Penn State College of Medicine researchers. Acetaminophen is a common drug used to treat a variety of issues, including fever, infection, muscle pain, headache, migraine, colds and allergies. Traditionally, … [Read more...]
Blood Levels of ‘Free Range’ DNA may Signal Early Detection of Dementia and Frailty
In a long-term prospective study of more than 600 older participants, Johns Hopkins Medicine researchers say they have evidence that higher levels of cell-free DNA circulating in the blood may signal increased risk of chronic inflammation associated with early signs of frailty and dementia. The findings, published Oct. 11 in the Journal of Alzheimer's Disease, could advance … [Read more...]
New Survey: 91% of Parents Say their family is less stressed when they eat together
Chronic, constant stress can increase lifetime risk of heart disease and stroke, but a new survey from the American Heart Association, a global force for longer, healthier lives for all, reveals regular mealtime with others could be a simple solution to help manage stress. Of the 1,000 U.S. adults nationwide surveyed in September 2022 for the American Heart Association's … [Read more...]
Widespread Metabolic Dysregulation in Different Organs in Type 2 Diabetes
Using state of the art techniques, researchers from Uppsala University have shown that the metabolism in patients with type 2 diabetes and prediabetes was much more disturbed than previously known, and that it varied between organs and severity of the disease. The study is a collaboration with e.g. Copenhagen University and AstraZeneca and it has been published in the journal … [Read more...]
Biological Pathways Provide Evidence For How to Overcome Barriers Limiting Cancer Immunotherapies
Researchers at UNC Lineberger Comprehensive Cancer Center have found a possible way to overcome barriers that block effective anti-cancer immune responses, thereby opening the potential for more effective immunotherapies in people. The findings are published in Nature. An unfavorable immune environment immediately surrounding a tumor cell is a major obstacle in using … [Read more...]
Researchers Find Tumor Microbiome Interactions may Identify New Approaches for Pancreatic Cancer Treatment
Investigators from Rutgers Cancer Institute of New Jersey, the state's leading cancer center and only National Cancer Institute-Designated Comprehensive Cancer Center, together with RWJBarnabas Health, examined the microbiome of pancreatic tumors and identified particular microorganisms at single cell resolution that are associated with inflammation and with poor survival. … [Read more...]
Scientists are One Step Closer to Stopping Drug-Resistant Tumors From Growing
Scientists have solved a long-standing mystery surrounding a cancer-promoting protein and how it causes tumor growth. The findings are an important step in the quest to make cancer drugs more effective since aggressive tumors often become adept at resisting drugs and other therapeutic agents. The recent discovery by a team of scientists including Benjamin Myers, PhD, an … [Read more...]
Antibiotics Given in Infancy May have Adverse Impact on Adult Gut Health.
Preterm and low birth weight babies are routinely given antibiotics to prevent, not just treat, infections, which they have a high risk of developing. A new study, published in The Journal of Physiology has found that early life exposure to antibiotics in neonatal mice has long-lasting effects on their microbiota, enteric nervous system, and gut function. This could mean that … [Read more...]
Problems Persist for Kids Exposed to Cannabis in the Womb
Children who were exposed to cannabis in the womb continue to show elevated rates of symptoms of psychopathology -- depression, anxiety and other psychiatric conditions -- even as, at ages 11 and 12, they head toward adolescence, according to research from the Department of Psychological & Brain Sciences' BRAIN Lab, led by Ryan Bogdan, associate professor in Arts & … [Read more...]
Front-Loading Calories Early in The Day Reduces Hunger but does not Affect Weight Loss
There's the old saying in dieting that one must "breakfast like a king, lunch like a prince, and dine like a pauper," based on the belief that consuming the bulk of daily calories in the morning optimizes weight loss by burning calories more efficiently and quickly. But according to a new study publishing September 9 in Cell Metabolism, whether a person eats their largest meal … [Read more...]
Scientists Redefine Obesity with Discovery of Two Major Subtypes
A team led by Van Andel Institute scientists has identified two distinct types of obesity with physiological and molecular differences that may have lifelong consequences for health, disease and response to medication. The findings, published today in the journal Nature Metabolism, offer a more nuanced understanding of obesity than current definitions and may one day inform … [Read more...]
Better Screening Could Predict and Prevent Sudden Cardiac Death in Young People
Nearly nine in ten cases of sudden cardiac death (SCD) due to hypertrophic cardiomyopathy (HCM) in young people are preceded by symptoms, ECG abnormalities or a positive family history, according to a new study published this week in the open-access journal PLOS ONE by Erik Börjesson of Sahlgrenska University Hospital, Sweden, and colleagues. Those findings suggest that … [Read more...]
Muscle Models Mimic Diabetes, Inform Personalized Medicine
Abnormally high blood sugar (glucose) levels can result in Type 2 diabetes when things go awry with the body's skeletal muscle, which plays a key role in regulating glucose. Scientists are using in vitro (in a dish) skeletal muscle engineering to gain a better understanding of the complex genetic and environmental factors underlying diabetes. This involves putting lab-grown, … [Read more...]
Researchers Identify a Drug that Mimics the Effects of Exercise on Muscle and Bone in Mice
Maintaining a regular workout routine can help you look and feel great -- but did you know that exercise also helps maintain your muscles and bones? People who are unable to engage in physical activity experience weakening of the muscles and bones, a condition known as locomotor frailty. Recently, researchers in Japan have identified a new drug that may aid in the treatment of … [Read more...]
Dental Biorhythm is Associated with Adolescent Weight Gain, Study Finds
An international research team led by Dr Patrick Mahoney at Kent's School of Anthropology and Conservation discovered the biorhythm in primary 'milk' molars (Retzius periodicity [RP]) is related to aspects of physical development during early adolescence. A faster dental biorhythm produced smaller gains in weight and mass. RP forms through a circadian-like process, occurring … [Read more...]
Parents Adopt Unhealthy Food Routines for Family Wellbeing in Place of Unaffordable Activities
New study study suggests a key reason parents on a low-income buy unhealthy foods for their families is to compensate for non-food related activities which support social wellbeing, but that they are unable to afford. The study from the Centre for Food Policy at City, University of London sheds light on the food buying habits of low-income parents across England. It looked … [Read more...]
Microneedling Beats Chemical Peels for Acne Scar Treatment
Chemical peels are a common treatment for acne scars, but a Rutgers study finds that microneedling is significantly more effective for patients with dark skin. Babar Rao, a professor of dermatology and pathology at Robert Wood Johnson Medical School, and fellow researchers randomly assigned 60 patients with acne scars and dark skin -- Fitzpatrick Skin Phototype IV to VI -- … [Read more...]
NIH Experts Review Monkeypox Challenges
Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), and H. Clifford Lane, M.D., NIAID deputy director for clinical research and special projects, discuss a published case series (JP Thornhill et al.) detailing the symptoms and outcomes of 528 people with monkeypox from 16 countries in five continents. The authors note that … [Read more...]
Study Uncovers Differences in Saliva Bacteria of Students with Recent Suicidal Thoughts
While there is a growing body of research on mental health and the human microbiome, this is the first study to look at bacterial differences in the saliva of those with and without recent suicidal thoughts, also called suicidal ideation. Recent suicidal ideation was defined as thoughts of suicide within the two weeks before the saliva sample was taken. Controlling for the … [Read more...]
Insufficient Sleep in Teenagers is Associated with Overweight and Obesity
Adolescents who sleep less than eight hours a night are more likely to be overweight or obese compared to their peers with sufficient sleep, according to research presented at ESC Congress 2022. Shorter sleepers were also more likely to have a combination of other unhealthy characteristics including excess fat around the middle, elevated blood pressure, and abnormal blood lipid … [Read more...]
Benefits of Statin Therapy Highlighted
Stopping statin treatment early could substantially reduce lifetime protection against heart disease since a large share of the benefit occurs later in life. That's the finding of a modelling study presented at ESC Congress 2022.1 Lead author Dr. Runguo Wu of Queen Mary University of London, UK said: "The study indicates that people in their 40s with a high likelihood of … [Read more...]
Boost in Rates of Type 2 Diabetes Among Children During COVID-19 Pandemic
In a multi-site study of medical records, researchers at Johns Hopkins Children's Center and across the United States say they have documented a steep rise in type 2 diabetes among children during the COVID-19 pandemic. In a report on the findings, published Aug. 17 in The Journal of Pediatrics, the investigators note it is unclear whether the virus infection itself was a … [Read more...]
New Research to Reduce Harm of Gestational Diabetes
A study of over 4,000 pregnant New Zealand women suggests the country can improve babies' health and reduce medical risks for mums by changing how gestational diabetes is diagnosed. The study assessed the value of lowering the blood-sugar threshold for diagnosis. The University of Auckland researchers, based at the Liggins Institute, tested the blood-sugar level currently … [Read more...]
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