Women Fitness

Women Fitness is an exhaustive resource on exercise for women, workouts for women, strength training, Zumba, HIIT, weight loss, workout, fitness tips, yoga, pregnancy.

  • Member’s Login
  • 150 Countries
  • Privacy Policy
  • Disclaimer
  • Site Map
  • Health & Fitness
  • Celebrities
  • News
  • Digital Magazine
  • Shopping
  • Print Magazine
    • Follow
    • Subscribe

Weight Management News

Satiety factor Associated with prolonged exercise

March 4, 2021 By Namita Nayyar (WF Team)

A drug that helps us to eat less could help the more than 650 million people around the world who live with obesity. One of the emerging drug candidates that interest researchers is the hormone GDF15 that, when given to rodents, lowers their appetite and body weight. New research from the University of Copenhagen finds that the body produces large amounts GDF15 during extended bouts of vigorous exercise, presumably as a physiological stress signal.

exercise

This finding highlights central differences between GDF15 given as a drug (pharmacology), and GDF15 released naturally in response to vigorous exercise (physiology). This is an important distinction in understanding GDF15’s role in appetite regulation and energy balance, with implications for its role as a possible anti-obesity drug.

“Whether there are any physiological conditions that implicates GDF15 as a regulator of energy metabolism remains an unsolved mystery,” says Associate Professor Christoffer Clemmensen from the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) at the University of Copenhagen.

Christoffer Clemmensen, PhD student Trine Sand Nicolaisen and Assistant Professor Anders Bue Klein led the research in collaboration with the Department of Nutrition Exercise and Sports at the University of Copenhagen and the findings were published in Nature Communications.

Their goal was to better understand the physiological role of GDF15 in energy metabolism and behavior.

Recent findings in rodents and monkeys suggest that the hormone, when administered pharmacologically, lowers appetite but also promotes nausea and sickness. Other studies have shown that the drug metformin promotes weight loss by increasing the levels of GDF15.

Different pharmocological and physiological effects of GDF15

Little is known about how GDF15 functions when released naturally by the body, however. The researchers set out to fill this knowledge gap with a series of experiments on humans and mice. Among their main findings was that prolonged exercise beyond two hours in humans results in a four to five-fold increase in the circulation of GDF15, suggesting that GDF15 functions as an exercise-induced stress signal.

To test this idea, the researchers used animal models. They found that giving GDF15 to mice as a drug clearly lowered their motivation to exercise and reduced their appetite. But when the mice were vigorously exercised, to stimulate the physiological release of GDF15, it did induce the same response on behavior and food intake.

These findings underscore a difference between physiological GDF15 and pharmacological GDF15. Christoffer Clemmensen stresses that more studies are needed to understand this mismatch and whether GDF15 also has behavioral effects in humans. He and his team will now focus on clarifying the effects of GDF15 when produced by the body.

News

  • Alternative Health News
  • Arthritis News
  • Asthma & Allergies News
  • Breast Cancer News
  • Cancer News
  • Cardiovascular Health News
  • Diabetes News
  • Fertility & Pregnancy News
  • Nutrition & Wellness News
  • Orthopedics News
  • Sports & Medicine News
  • Weight Management News
  • Women Beauty News
  • Women Health News
  • Other News

Download Women Fitness App

Namita Nayyar
President
Women Fitness
Launches First Book

A rare insight into the life of 15 Track and Field Women World and Olympic Champions


Paperback Edition



Kindle Edition

Digital Magazine Sign-Up

NewsLetter Sign-Up

 

Digital Magazine Available On

Available On Readly App

Available On Magzter

Advertise With Us











Women Fitness App
Download Women Fitness App


  • facebook
  • Twitter
  • Linkedin
  • Pinterest
  • Instagram

For More Fitness Tips & Secrets, Join Our Mailing List!

JOIN WF

  • Newsletter Signup
  • Why WF
  • Advertise With Us
  • Digital Magazine
  • Print Magazine

Absolutely Free

  • WF Categories
  • Fitness Tools
  • Low Calorie Recipes
  • Calorie Catch
  • WF Entertainment

All About Us

  • About Namita
  • Team
  • Achievements
  • Testimonials
  • Contact Us

© by Womenfitness.net 1999–2023. All rights reserved.

All Categories

  • What’s New
  • Weight Loss
    • Obesity
    • Low Calorie Recipes
    • Real Weight Loss Stories
    • Fitness Tools
    • Daily Tip
    • Fitness Analysis
    • Motivation of the Day
  • Exercise
    • Body building
    • Fitness for Models
    • Target Abs
    • Women At 40
    • Motivation Point
  • Healthy Eating
    • Calorie Catch
    • Disease Management
    • Good health
    • Herbs
  • Beauty & Fashion
    • Eye Care
    • Hair Care
    • Hand & Foot Care
    • Make Up
    • Skin Care
    • Beauty Tip
  • Celebrities
    • Actresses
    • Celebrities & Fitness Trainers
    • Sportswomen
    • Celebrity List
  • Pregnancy
    • Fertility & Conception
    • Health During Pregnancy
    • Getting Back to Normal
    • Problems in Pregnancy
    • Due Date calculator
    • Sexual Health
  • Yoga
    • Beauty & Yoga
    • Yoga during Pregnancy
    • Meditation Point
    • The Yogic Diet
    • Weight loss Yoga
    • Yog – Asanas
    • Yoga & Disease Management
    • Yoga in Action
  • Contact
    • About Namita
    • Our Team
    • Advertize with Us
    • FAQ
    • Message Board
    • Contact Us
  • Shopping
    • Book & Mag. Store
    • Fitness Apparels
    • Fitness Music
    • Fitness Dvd’s
    • Maternity Store
    • Sports & Outdoors
    • Health Care Store
    • Natural Health Foods
    • Herbs & Spices
    • Beauty Shop
    • Jewelry Store
    • Flowers
    • Health Care Equip.
    • Diet & Nutrition
    • Health Mobile Apps
    • Sex Lubes Store
  • More
    • Testimonials
    • Awards
    • WF Links
    • Privacy Policy
    • Site Map
    • Disclaimer
    • News
    • Member’s Area
    • Reviews

Follow

  • facebook
  • Twitter
  • Linkedin
  • Pinterest
  • Instagram
Go to mobile version