Cancer

A panel of 55 genes, almost all of which are impacted by the loss of a particular protein, appears to predict if breast cancer will become invasive, leading to poorer survival, researchers at Georgetown Lombardi Comprehensive Cancer Center report in PLOS ONE. The panel represents loss of a powerful tumor suppressor gene, SYK, as well as genetic alterations in 51 other genes … [Read more...]

Researchers at the UNC School of Medicine conducted a comprehensive genetic analysis of invasive bladder cancer tumors to discover that the disease shares genetic similarities with two forms of breast cancer. The finding is significant because a greater understanding of the genetic basis of cancers, such as breast cancers, has in the recent past led to the development of new … [Read more...]

Dartmouth-Hitchcock Norris Cotton Cancer Center has treated three men with a recently FDA-approved treatment, which offers new options for men whose prostate cancer has spread to their bones. The treatment's trade name is Xofigo® (or radium-223 dichloride). It is an alpha particle-emitting radioactive therapeutic agent with an anti-tumor effect. Treatment entails an … [Read more...]

Light therapy decreased depressive symptoms and normalized circadian rhythms among cancer survivors, according to new research from the Icahn School of Medicine at Mount Sinai presented at the American Psychosomatic Society in Denver, CO. Researchers from Icahn School of Medicine at Mount Sinai, Northwestern University in Chicago, University of Iowa, University of California … [Read more...]

Consuming a diet with a high glycemic index, a classification of how rapidly carbohydrates elevate blood sugar levels, was independently associated with an increased risk of developing lung cancer in non-Hispanic whites, according to a new epidemiologic study from The University of Texas MD Anderson Cancer Center. This research, published in Cancer Epidemiology, Biomarkers … [Read more...]

Scientists from the Cancer Therapy & Research Center (CTRC) in San Antonio published work that provides deeper insight into how the Angelina Jolie gene, BRCA1, functions in normal breast tissue and how its loss results in breast cancer. The CTRC -- a National Cancer Institute-designated Cancer Center -- is part of UT Medicine San Antonio, the clinical practice of the … [Read more...]

Ovarian cancer is called the silent killer because by the time most women get diagnosed, it’s too late. Most women mistake the symptoms for constipation. But now, dogs are sticking their nose in the middle of a groundbreaking study, and it could be the key to an early diagnosis. When it comes to the sense of smell, dogs beat us out 10,000 to one. Cynthia M. Otto, DVM, … [Read more...]

Scientists from Queen Mary University of London have made a breakthrough in developing a new therapy for advanced bladder cancer -- for which there have been no major treatment advances in the past 30 years. Published today in Nature, the study examined an antibody (MPDL3280A) which blocks a protein (PD-L1) thought to help cancer cells evade immune detection. In a phase … [Read more...]

A new study has found women who smoke when pregnant are putting their daughters at a greater risk of developing ovarian and breast cancer later in life. The Australian National University (ANU) study, published in Human Reproduction, found mothers who reported smoking most days while pregnant had daughters who had an earlier age of first menstruation, or menarche. Lead … [Read more...]

One of the family of drugs prescribed for rheumatoid arthritis and other inflammatory conditions is called TNF inhibitors. They act by dampening part of the immune system called tumor necrosis factor (TNF). In one of the balancing acts of medicine, the anti-inflammatory action of the drug also increases the risk for other conditions, in this case, a rare form of eye cancer, … [Read more...]

Over the past decade, studies have found that obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer. Now, a new study from Whitehead Institute and MIT's Koch Institute for Integrative Cancer Research reveals how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous. The study of mice suggests … [Read more...]

A University of Central Florida chemist has come up with a unique way to kill certain cancer cells -- give them acid reflux. Chemistry professor Kevin Belfield used a special salt to make cancer cells more acidic -- similar to the way greasy foods cause acid reflux in some people. He used a light-activated, acid-generating molecule to make the cells more acidic when exposed … [Read more...]

A new study provides a major link between low levels of vitamin D and aggressive prostate cancer. Northwestern Medicine research showed deficient vitamin D blood levels in men can predict aggressive prostate cancer identified at the time of surgery. The finding is important because it can offer guidance to men and their doctors who may be considering active surveillance, in … [Read more...]

Scientists at the University of Kansas Medical Center have determined that high doses of vitamin C, administered intravenously with traditional chemotherapy, helped kill cancer cells while reducing the toxic effects of chemotherapy for some cancer patients. By evaluating the therapy in cells, animals, and humans, the researchers found that a combination of infused vitamin C … [Read more...]

Nearly two-thirds of the herbal medicines used by cancer patients in the Middle East have potential health risks, according to a new survey led by Assistant Professor Eran Ben-Arye, of the Technion-Israel Institute of Technology. The study published in the journal Cancer concludes that herbal remedies such as turmeric may increase the toxic effects of certain chemotherapies, … [Read more...]

Men who walked at a fast pace prior to a prostate cancer diagnosis had more regularly shaped blood vessels in their prostate tumors compared with men who walked slowly, providing a potential explanation for why exercise is linked to improved outcomes for men with prostate cancer, according to results presented at the AACR-Prostate Cancer Foundation Conference on Advances in … [Read more...]

Intakes of dietary or supplemental antioxidants were not associated with a decreased risk of prostate cancer among men in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, according to a study in the February 15 issue of the Journal of the National Cancer Institute . The study did find that vitamin E and beta-carotene supplementation may be associated … [Read more...]

Researchers are cautious about cancer patients taking vitamin C supplements Researchers at Memorial Sloan-Kettering Cancer Center have found that cancer tumors consume large amounts of vitamin C. Their findings, which are reported in the September 15 issue of Cancer Research, may shed new light on the nutritional needs of tumors. "This study is the first to demonstrate … [Read more...]

For people with brain tumors, treatment usually involves invasive surgery as surgeons open portions of the skull to remove the cancer. If a tumor comes back, patients may begin to run out of options.  A new FDA- approved device, also used to treat epilepsy, is now giving some patients another chance. Sixty-five-year-old Linda Fahey is writing a book, but weakness on her left … [Read more...]

Using a nomogram that incorporates age, Gleason score, and prostate-specific antigen (PSA) level at diagnosis, individual risks that a screen-detected prostate cancer has been overdiagnosed can be estimated, according to a new study published January 6 in the Journal of the National Cancer Institute. The authors used a standard definition of overdiagnosis to refer to a … [Read more...]

Studies have found that prostate cancer is over-diagnosed in up to 42 percent of cases, prompting men to receive unnecessary treatment that can cause devastating side effects, including impotence and incontinence. Now, researchers at Fred Hutchinson Cancer Research Center and the University of Washington have developed a personalized tool that can predict the likelihood of … [Read more...]

Microtubules, one component of a cell’s skeleton, are hollow tubes formed from the polymerization of α- and β-tubulin, which are themselves important structural proteins of the mitotic spindle that equally separates chromosomes during cell division. As such, several α/β-tubulin inhibitory agents are used as therapeutic drugs against cancer cells, which are undergoing vigorous … [Read more...]

Up to half of women with advanced-stage ovarian cancer might be cured, compared to the current 20 per cent survival rate, argues Dr. Steven Narod, senior scientist at Women's College Research Institute, who calls for a new standard of treatment for women with late-stage ovarian cancer. Based on an analysis of existing evidence, published in an opinion article in the Nature … [Read more...]

A multicenter research team has identified a biomarker that predicts which stage II colon cancer patients may benefit from chemotherapy after surgery to prevent a recurrence of their disease. The study was published in the online edition of the New England Journal of Medicine. The majority of patients with stage II colon cancer--cancer that has grown into or through the … [Read more...]

Patients with advanced cancers have new hope thanks to immunotherapy. It’s a therapy that trains the body’s own immune system to search out and destroy the cancer cells.  Researchers say they’ve found an accurate way to screen the patients who may respond well to this treatment. For 25-year-old Stefanie Joho, her three sisters and parents are her world. Three years ago … [Read more...]

This year alone, 21,000 women will be diagnosed with ovarian cancer. Of those, 14,000 will die. Because the symptoms are so subtle, most women aren’t diagnosed until they are in the late stages of the disease.  Now there is a new treatment that is bringing hope to some patients who have exhausted all other options. Fifty-seven-year-old Connie Scrivens is returning to normal … [Read more...]

Obesity has long been associated with increased risk of colorectal cancer, but the link has never been understood. Now, a research team led by investigators at Thomas Jefferson University has revealed the biological connection, and in the process, has identified an approved drug that might prevent development of the cancer. Their study is published in Cancer Research. In … [Read more...]

Obesity has direct consequences on health and is associated with the onset of aggressive cancers, but the mechanisms underlying this phenomenon are little known. Researchers from the Institut de Pharmacologie et he Biologie Structurale (CNRS/Université Toulouse III -- Paul Sabatier) have recently elucidated one of these mechanisms in prostate cancer, one of the most common … [Read more...]

The genes that cause cancer are so tiny, yet so complex, that finding something to destroy or stop them is one of the top struggles for cancer researchers today. At The University of Kansas Cancer Center, understanding these microscopic processes and making drug discoveries is a priority in helping make the road for cancer patients easier and curbing recurrence. Liang Xu, … [Read more...]