Breast Cancer

An increase in women with breast cancer choosing double mastectomy may be influenced by media coverage of celebrities, a new study finds. From 2000 to 2012, 17 celebrities publicly disclosed their breast cancer diagnosis and treatment. Researchers from the University of Michigan analyzed 727 articles from major U.S. print publications that covered these celebrity diagnoses. … [Read more...]

Protective mastectomies that preserve the nipple and surrounding skin prevent breast cancer as effectively as more invasive surgeries for women with a genetic mutation called BRCA that raises their risk of developing breast cancer, a multi-institution study led by Mayo Clinic found. The research should reassure patients and surgeons that nipple-sparing mastectomies, which leave … [Read more...]

Infertility and hormonal fertility treatments may influence the amount of dense tissue in the breast, a risk factor for breast cancer, according to a study involving 43,313 women, published in the open access journal Breast Cancer Research. Researchers at Karolinska Institutet, Sweden found that women with a history of infertility had denser breasts than other women. The … [Read more...]

Harvard Stem Cell Institute (HSCI) researchers at Dana-Farber Cancer Institute (DFCI) and collaborators at Brigham and Women's Hospital (BWH) have identified a molecular marker in normal breast tissue that can predict a woman's risk for developing breast cancer, the leading cause of death in women with cancer worldwide. The work, led by HSCI principal faculty member Kornelia … [Read more...]

Tallahassee resident Jennie Simons couldn't even reach over her head by the time she had finished her breast cancer treatment in 2008. She was a survivor, beating back a particularly aggressive case of breast cancer -- first in 2000 and then again in 2008 when it recurred -- but the chemotherapy left her body ravaged. She had 15 surgeries during the breast reconstruction … [Read more...]

A new study finds that the majority of women who undergo mastectomy for breast cancer go on to get breast reconstruction, a practice that has increased dramatically over time. Researchers found that 46 percent of patients received reconstruction in 1998 but that figure rose to 63 percent by 2007. "Breast reconstruction has a big impact on quality of life for breast cancer … [Read more...]

Women with BRCA-related breast cancer who have a double mastectomy are nearly 50 per cent less likely to die of breast cancer within 20 years of diagnosis compared to women who have a single mastectomy, according to a new study led by Women's College Hospital's Kelly Metcalfe. The findings, published in the British Medical Journal, suggest a double mastectomy may be an … [Read more...]

Scientists from The University of Manchester working with IBM Research have identified a key biological mechanism that for the first time explains why women with dense breast tissue are at greater risk of developing breast cancer. The research, published in the journal Cell Cycle, has important implications for future cancer prevention and treatment. Women with higher … [Read more...]

A series of simple telephone calls can make a profound difference in helping women to meet their treatment goals for breast cancer, according to a randomized trial of women who are also obese, published online today in Journal of Clinical Oncology by Dr. Pamela Goodwin of Mount Sinai Hospital and the Lunenfeld-Tanenbaum Research Institute. Women who received advice about … [Read more...]

New research looking at the biological process involved in breast cancer development has strengthened the argument for a potential link between alcohol consumption and the disease. Scientists from The University of Manchester -- part of the Manchester Cancer Research Centre -- and the University of Salford looked at a particular enzyme, a biological molecule that accelerates … [Read more...]

Tamoxifen, a drug currently used to treat breast cancer, also kills a fungus that causes a deadly brain infection in immunocompromised patients. The findings, which could lead to new treatments for a disease that kills more HIV/AIDS patients than tuberculosis, appear in mBio®, the online open-access journal of the American Society for Microbiology (ASM.) "This work sets the … [Read more...]

A new study led by University of Kentucky Markey Cancer Center researcher Peter Zhou shows that targeting Twist, a nuclear protein that is an accelerant of the epithelial-mesenchymal transition (EMT) program in human cells, may provide an effective approach for treating triple-negative breast cancer. Triple-negative breast cancer has an activated EMT program, which is a … [Read more...]

A UCLA researcher has analyzed the long-term outcomes in postmenopausal women who took two widely used breast cancer treatments and found that although both drugs were safe and effective, and had no detrimental effect on overall quality of life, there were some differences in the type and severity of symptoms the women experienced with each treatment, and these especially … [Read more...]

Young women who smoke and have been smoking a pack a day for a decade or more have a significantly increased risk of developing the most common type of breast cancer. That is the finding of an analysis published early online in Cancer, a peer-reviewed journal of the American Cancer Society. The study indicates that an increased risk of breast cancer may be another health risk … [Read more...]

Omega-3 fatty acids may lower the risk of breast cancer in postmenopausal obese women, according to researchers. The protection likely comes from the fatty acids' anti-inflammatory effects, said Dr. Andrea Manni, professor and division chief of endocrinology, diabetes and metabolism, Penn State College of Medicine. Obesity is a major breast cancer risk factor in … [Read more...]

Preventing cancer requires intimate knowledge of how cancer starts, what causes it to grow and flourish, and how to stop it in its tracks. Sometimes this comes in the form of a vaccine (the HPV vaccine for cervical and head and neck cancers), a screening (a colonoscopy for colorectal cancer) or a blood test (the PSA level test for prostate cancer). Carol Fabian, M.D., … [Read more...]

So far, studies have suggested no significant association between red meat intake and breast cancer. However, most have been based on diet during midlife and later, and many lines of evidence suggest that some exposures, potentially including dietary factors, may have greater effects on the development of breast cancer during early adulthood. So a team of US researchers … [Read more...]

Massachusetts General Hospital (MGH) investigators may have uncovered a novel mechanism behind the ability of obesity to promote cancer progression. In their report published online in the journal Clinical Cancer Research, the research team describes finding an association between obesity and an overabundance of a factor called PlGF (placental growth factor) and that PlGF's … [Read more...]

Dartmouth researchers have found that reducing carbohydrate intake could reduce the risk of breast cancer recurrence among women whose tumor tissue is positive for the IGF-1 receptor. The study, "Risk of Breast Cancer Recurrence Associated with Carbohydrate Intake and Tissue Expression of IGFI Receptor," will appear in the July issue of Cancer Epidemiology Biomarkers & … [Read more...]

Folic acid supplements at levels consumed by breast cancer patients and survivors in North America promoted the growth of existing breast cancer in rats, new research found. The role of folate, a B vitamin, and its synthetic form, folic acid, in the development and progression of breast cancer is highly controversial. Although some studies have found it may offer protection … [Read more...]

Nearly 70 percent of patients with advanced breast cancer experience skeletal metastasis, in which cancer cells migrate from a primary tumor into bone -- a painful development that can cause fractures and spinal compression. While scientists are attempting to better understand metastasis in general, not much is known about how and why certain cancers spread to specific organs, … [Read more...]

For women undergoing breast cancer surgery, a technique called lipofilling -- using the patient's own fat cells to optimize the results of breast reconstruction -- does not increase the risk of recurrent breast cancer, reports a study in the February issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons … [Read more...]

In a review article published in the Feb. 4 issue of the New England Journal of Medicine, a pair of Mayo Clinic Cancer Center researchers provide an in-depth look at the issues associated with the care of women in families with hereditary breast and ovarian cancer syndrome who have not yet developed cancer themselves. The article addresses optimal risk assessment for breast and … [Read more...]

According to the United States Centers for Disease Control and Prevention, breast cancer is the most common cancer in women. For patients whose breast cancers are hormone-dependent, current treatment focuses on using drugs that block estrogen (a type of hormone) from attaching to estrogen receptors on tumor cells to prevent the cells from growing and spreading. In a new … [Read more...]

A pair of Yale Cancer Center interventional studies involving breast cancer survivors found that lifestyle changes in the form of healthy eating and regular exercise can decrease biomarkers related to breast cancer recurrence and mortality. The abstracts are scheduled to be presented at the 2014 annual meeting of the American Society of Clinical Oncology in Chicago May 30-June … [Read more...]

A doctor treating a patient with a potentially fatal metastatic breast tumor would be very pleased to find, after administering a round of treatment, that the primary tumor had undergone a change in character -- from aggressive to static, and no longer shedding cells that can colonize distant organs of the body. Indeed, most patients with breast and other forms of cancer who … [Read more...]

Adoption of new guidelines recommending screening mammography every two years for women ages 50 to 74 would result in breast cancer screening that is equally effective, while saving the United States $4.3 billion a year in health care costs, according to a study led by UC San Francisco. The study compares three possible mammography screening strategies with a model of … [Read more...]

Researchers from University Hospitals (UH) Case Medical Center and Case Western Reserve University School of Medicine have published new findings in the February issue of American Journal of Roentgenology that mammography remains beneficial for women in their 40s. According to the study, women between ages 40 and 49 who underwent routine screening mammography were diagnosed at … [Read more...]