Breast cancer patients who have radiotherapy targeted at the original tumour site experience fewer side effects five years after treatment than those who have whole breast radiotherapy, and their cancer is just as unlikely to return, according to trial results published in The Lancet. The Cancer Research UK-funded IMPORT LOW trial revealed that five years after … [Read more...]
Breast Cancer
Impact of surgical modality on breast-specific sensuality
Does the type of surgery used to treat breast cancer impact a woman's sensuality and sexual function in survivorship? New research from Women & Infants Hospital analyzed the association of surgical modality with sexual function and found that breast-specific sensuality and appearance satisfaction are better with lumpectomy and may correlate with improved sexual function … [Read more...]
Regular use of aspirin can lower risk of breast cancer for women
A City of Hope-led study found that the use of low-dose aspirin (81mg) reduces the risk of breast cancer in women who are part of the California's Teacher's Study. This study -- which is the first to suggest that the reduction in risk occurs for low-dose aspirin -- was proposed by City of Hope's Leslie Bernstein, Ph.D., professor and director of the Division of Biomarkers of … [Read more...]
Alcohol is associated with higher risk of breast cancer in African-American women
Alcohol consumption was associated with an increased risk of breast cancer in a large study of African-American women, indicating that they, like white women, may benefit from limiting alcohol. These study results have been published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. The lead author is Melissa A. … [Read more...]
Blood test that detects changes in tumor DNA predicts survival of women with advanced breast cancer
Results of a multicenter study of 129 women with advanced breast cancer show that a blood test that spots cancer-linked DNA correctly predicted that most of those patients with higher levels of the tumor markers died significantly earlier than those with lower levels. The Johns Hopkins Kimmel Cancer Center scientists, who developed the test and led the study, say the … [Read more...]
Breast density matters in detection of breast cancer
Almost 8% of women have extremely high breast density, which can make it harder for health professionals to detect breast cancer on a screening mammogram. These women are also more likely to develop breast cancer in the future. This is the warning from a new Australian alliance of breast cancer researchers, who are working together to raise awareness of the issue in the … [Read more...]
Revealed! Dense-dose chemotherapy for early breast cancer does not result in significant improvement
Among women with high-risk early breast cancer, the use of tailored dose-dense chemotherapy compared with standard adjuvant chemotherapy did not result in a statistically significant improvement in breast cancer recurrence-free survival, and nonhematologic toxic effects were more frequent in the tailored dose-dense group, according to a study appearing in the November 8 issue … [Read more...]
Innovative drug could revolutionize the treatment of early-stage breast cancer
The large-scale international study ABCSG 42/PALLAS is currently investigating whether a drug that is already showing great promise in the treatment of metastasised breast cancer might also increase the success of treatment of the most common type of breast cancer: early-stage hormone-receptor-positive, HER2-negative breast cancer. The study is being conducted in the USA and in … [Read more...]
New Drug that may fight breast cancer
Researchers are looking at a drug once used to improve blood flow in damaged hearts in thousands of patients as a possible treatment option for triple negative breast cancer (TNBC). Cancer researchers at Houston Methodist Hospital want to know if combining nitric oxide synthase inhibitor Tilarginine Acetate (L-NMMA) and standard chemotherapy is a safe treatment option … [Read more...]
Study finds ‘striking’ use of double mastectomy
Nearly half of early stage breast cancer patients considered having double mastectomy and one in six received it -- including many who were at low risk of developing a second breast cancer, a new study finds. Many patients who chose double mastectomy demonstrated little knowledge of the lack of benefit this aggressive procedure has for most patients. "That 1 in 6 … [Read more...]
Social isolation may worsen breast cancer prospects
Patients with early breast cancer who are socially isolated have a higher risk of dying from their disease, a new study suggests. Women with fewer social ties — to friends, family, community and religious groups, as well as spouses or romantic partners — were 43 percent more likely to see their breast cancer return, 64 percent more likely to die from breast cancer … [Read more...]
Breast Cancer Drugs Tied to Blood Vessel Damage
Women on breast cancer drugs called aromatase inhibitors may show signs of early blood vessel damage that could lead to heart disease, a small study suggests. Researchers found that compared with healthy women their age, women on aromatase inhibitors were more likely to show signs of "endothelial dysfunction." That refers to problems in how the blood vessel lining … [Read more...]
Most women unaware of breast density’s effect on cancer risk
Most women don't know that having dense breasts increases their risk for breast cancer and reduces a mammogram's ability to detect cancer, according to a University of Virginia School of Medicine study. A random phone survey of 1,024 Virginia women ages 35 to 70, conducted by the UVA Center for Survey Research, found that just 1 in 8 women were aware that breast density … [Read more...]
Viral particles support prophylactic vaccination against breast cancer
Artificial structures of tumour antigens, so-called mimotopes, applied in vaccinations of cancer patients can trigger a long-term immune response. For the vaccine, however, a carrier is required that triggers an immune response itself. A team of researchers from the Messerli Research Institute at the University of Veterinary Medicine Vienna, and the Medical University of Vienna … [Read more...]
Gene therapy technique may help prevent cancer metastasis
The spread of malignant cells around the body, known as metastasis, is the leading cause of mortality in women with breast cancer. Now, a new gene therapy technique being developed by researchers at MIT is showing promise as a way to prevent breast cancer tumors from metastasizing. The treatment, described in a paper published in the journal Nature Communications, uses … [Read more...]
New Details About Breast Cancer Tumor Growth
As with most cancers, triple-negative breast cancer (TNBC) cells have abnormal amounts of chromosomes or DNA copy number aberrations (CNAs) in their genomes. A new study used single cell sequencing technology to provide previously unknown details about how and when CNAs impact tumor formation and growth, information that may have significant implications for diagnosis and … [Read more...]
Exercise Improves Memory in Breast Cancer Survivors
Moderate-to-vigorous physical activity is related to improved subjective memory in breast cancer survivors, who often complain about memory problems, reports a new Northwestern Medicine study. It appears the physical activity alleviates stress and benefits women psychologically, which in turn aids their memory. A surprising finding is memory problems appear to be … [Read more...]
Proteins Can Help Save Breast Cancer Patients
A family of proteins that help cancer cells survive and spread around the body may be associated with improved prognosis for some women receiving treatment for breast cancer, research has shown. The study, led by academics at The University of Nottingham and published online by the academic journal Oncotarget, discovered that when high levels of the protein calpain … [Read more...]
Bacteria may protect you from breast cancer
Bacteria that have the potential to abet breast cancer are present in the breasts of cancer patients, while beneficial bacteria are more abundant in healthy breasts, where they may actually be protecting women from cancer, according to Gregor Reid, PhD, and his collaborators. These findings may lead ultimately to the use of probiotics to protect women against breast … [Read more...]
Understanding the resistance to treatments against breast cancer
Estrogens are responsible for the survival and proliferation of tumor cells in 70% of all breast cancer cases. The most frequently used treatment to fight this variety of tumors relies on anti-estrogens such as tamoxifen. However, nearly a third of the patients develop a resistance to this type of therapy after a few years. In a study published in the journal Nucleic Acids … [Read more...]
Smoking can hamper breast cancer treatment
We know that individuals who smoke take major health risks. Now a new research study from Lund University in Sweden shows that common treatment for breast cancer works less well in patients who smoke, compared to non-smokers. "Smokers who were treated with aromatase inhibitors had a three times higher risk of recurrence of breast cancer compared with the … [Read more...]
Radiation Course for Early-stage Breast Cancer
According to a recent research conducted at The University of Texas MD Anderson Cancer Center, it has been found that early-stage breast cancer patients receiving a shorter course of whole breast radiation with higher radiation doses per fraction reported equivalent cosmetic, functional and pain outcomes over time as those receiving a longer, lower-dose per fraction course of … [Read more...]
Blood test supports use of potential new treatment for patients with stomach cancer
At the American Society for Clinical Oncology (ASCO) Annual Meeting 2016, researchers present results of three clinical trials using new targeted therapies against triple negative breast cancer (TNBC). Each therapy uses a distinct strategy influenced by the immune system and all three have real potential to extend the lives of women whose cancers have progressed after previous … [Read more...]
International trial changing standard of care for advanced breast cancer reveals University of Pittsburgh Cancer Institute
Surgery to remove the primary tumor in women diagnosed with stage IV breast cancer, followed by the standard combination of therapies, adds months to the patients' lives, compared with standard therapy alone, an international clinical trial led by a University of Pittsburgh Cancer Institute (UPCI) professor revealed. The results of the phase III randomized, controlled trial … [Read more...]
Scientists block Breast Cancer Cells from hiding in bones of mice, prompting hope for Human Trials: Duke University Study
Scientists have successfully blocked breast cancer cells from entering and hiding in the bones of mice, where they can survive chemotherapy treatment. Researchers at have also devised a method of flushing breast cancer cells out of bone marrow in mice, making them easier to eradicate through conventional treatments or by the immune system. The findings, published in the … [Read more...]
Intake of dietary fat in adolescence associated with breast density: University of Maryland Study
Consuming high amounts of saturated fat or low amounts of mono- and polyunsaturated fats as an adolescent was associated with higher breast density in young adulthood. Breast density is a risk factor for breast cancer. The new work has been published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. Authors are … [Read more...]
Snoring, lack of sleep may reduce breast cancer survival
Women who sleep for shorter periods and experience frequent snoring prior to a breast cancer diagnosis may have a poorer prognosis. This is the finding of a new study published in the Journal of Clinical Sleep Medicine. Inadequate sleep duration combined with frequent snoring prior to a breast cancer diagnosis may reduce survival from the disease, say researchers. Breast … [Read more...]
Breakthrough approach to breast cancer treatment: A Study
In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers -- triple negative breast cancer. "This is the first … [Read more...]
Vitamin D increases breast cancer patient survival: University of California Study
Breast cancer patients with high levels of vitamin D in their blood are twice as likely to survive the disease as women with low levels of this nutrient, report University of California, San Diego School of Medicine researchers in the March issue of Anticancer Research. In previous studies, Cedric F. Garland, DrPH, professor in the Department of Family and Preventive … [Read more...]
Breast conserving therapy or mastectomy better for early breast cancer: A Danish Study
Young women with early breast cancer face a difficult choice about whether to opt for a mastectomy or breast conserving therapy (BCT). This is because there is little evidence as to whether the greater risk of a return of the disease at the site of the original tumour after BCT is linked to a greater risk of the cancer spreading to other parts of the body, leading to higher … [Read more...]
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